135067-76-4Relevant articles and documents
Synthesis of 5-arylthiouridines via electrophilic substitution of 5- bromouridines with diaryl disulfides
Hirota, Kosaku,Tomishi, Tetsuo,Maki, Yoshifumi,Sajiki, Hironao
, p. 161 - 173 (2007/10/03)
Novel synthetic method of 5-arylthiouridine derivatives is described. Treatment of 5-bromo-2',3'-O-isopropylideneuridine (1a) with diaryl disulfides in the presence of sodium hydride at ambient temperature gave the 5-arylthiouridines (2) in moderate yields. The present method is devised by virtue of a combination of efficient participation of the 5'-hydroxy group onto the uracil ring and the electrophilic nature of diaryl disulfide, which was applied to the synthesis of 5-arylthio-1-β-D-arabinofuranosyluracils (8).