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1351501-44-4

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1351501-44-4 Usage

Description

[2-fluoro-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)benzyl]carbamic acid tert-butyl ester is a synthetic compound characterized by its unique chemical structure, which includes a fluorine atom and a boron-containing ring. This structure, along with the presence of a tert-butyl ester group, makes it a versatile and potentially valuable compound for various applications in the field of organic chemistry.

Uses

Used in Organic Chemistry:
[2-fluoro-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)benzyl]carbamic acid tert-butyl ester is used as a synthetic intermediate for various chemical reactions and transformations. Its unique structure and reactivity make it a promising candidate for the development of new compounds and materials.
Used in Pharmaceutical Development:
In the pharmaceutical industry, [2-fluoro-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)benzyl]carbamic acid tert-butyl ester is used as a key building block for the synthesis of novel drug candidates. Its unique structure and reactivity can be exploited to design and develop new therapeutic agents with improved efficacy and selectivity.
Used in Agrochemicals:
[2-fluoro-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)benzyl]carbamic acid tert-butyl ester may also find applications in the agrochemical industry, where it can be used as a starting material for the development of new pesticides, herbicides, or other agricultural chemicals.
Used in Materials Science:
The unique structure and reactivity of [2-fluoro-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)benzyl]carbamic acid tert-butyl ester make it a potential candidate for the development of new materials with specific properties, such as improved mechanical strength, thermal stability, or chemical resistance.
Further research and exploration of the properties and applications of [2-fluoro-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)benzyl]carbamic acid tert-butyl ester may reveal new and exciting uses for this chemical in various industries, including pharmaceuticals, agrochemicals, and materials science.

Check Digit Verification of cas no

The CAS Registry Mumber 1351501-44-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,5,1,5,0 and 1 respectively; the second part has 2 digits, 4 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1351501-44:
(9*1)+(8*3)+(7*5)+(6*1)+(5*5)+(4*0)+(3*1)+(2*4)+(1*4)=114
114 % 10 = 4
So 1351501-44-4 is a valid CAS Registry Number.

1351501-44-4Relevant articles and documents

Matrix Metalloproteinase 13 Inhibitors for Modulation of Osteoclastogenesis: Enhancement of Solubility and Stability

Knapinska, Anna M.,Singh, Chandani,Drotleff, Gary,Blanco, Daniela,Chai, Cedric,Schwab, Jason,Herd, Anu,Fields, Gregg B.

, p. 1133 - 1142 (2021)

Matrix metalloproteinase 13 (MMP-13) activity has been correlated to breast cancer bone metastasis. It has been proposed that MMP-13 contributes to bone metastasis through the promotion of osteoclastogenesis. To explore the mechanisms of MMP-13 action, we previously described a highly efficacious and selective MMP-13 inhibitor, RF036. Unfortunately, further pursuit of RF036 as a probe of MMP-13 in vitro and in vivo activities was not practical due to the limited solubility and stability of the inhibitor. Our new study has explored replacing the RF036 backbone sulfur atom and terminal methyl group to create inhibitors with more favorable pharmacokinetic properties. One compound, designated inhibitor 3, in which the backbone sulfur and terminal methyl group of RF036 were replaced by nitrogen and oxetane, respectively, had comparable activity, selectivity, and membrane permeability to RF036, while exhibiting greatly enhanced solubility and stability. Inhibitor 3 effectively inhibited MMP-13-mediated osteoclastogenesis but spared collagenolysis, and thus represents a next-generation MMP-13 probe applicable for in vivo studies of breast cancer metastasis.

Development of matrix metalloproteinase-13 inhibitors – A structure-activity/structure-property relationship study

Fuerst, Rita,Yong Choi, Jun,Knapinska, Anna M.,Smith, Lyndsay,Cameron, Michael D.,Ruiz, Claudia,Fields, Gregg B.,Roush, William R.

supporting information, p. 4984 - 4995 (2018/09/27)

A structure-activity/structure-property relationship study based on the physicochemical as well as in vitro pharmacokinetic properties of a first generation matrix metalloproteinase (MMP)-13 inhibitor (2) was undertaken. After systematic variation of inhi

HETEROARYL COMPOUNDS AS BTK INHIBITORS AND USES THEREOF

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Paragraph 0396, (2016/05/02)

The present invention relates to imidazo pyridine compounds, and pharmaceutically acceptable compositions thereof, useful as BTK inhibitors.

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