135154-88-0

Basic information

• Product Name: (S)-4,4,4-TRIFLUOROBUTANE-1,3-DIOL
• Synonyms: (S)-4,4,4-TRIFLUOROBUTANE-1,3-DIOL;S-TFBDOL;(3S)-4,4,4-Trifluorobutane-1,3-diol;S-TFBDOL, (2S)-2,4-Dihydroxy-1,1,1-trifluorobutane;1,3-Butanediol,4,4,4-trifluoro-, (S)- (9CI)
• CAS NO: 135154-88-0
• Molecular Formula: C₄H₇F₃O₂
• Molecular Weight: 144.09
• Mol File: 135154-88-0.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 188.1 °C at 760 mmHg
• Flash Point: 67.6 °C
• Appearance: /
• Density: 1.354 g/cm³
• Vapor Pressure: 0.168mmHg at 25°C
• Refractive Index: 1.37
• Storage Temp.: 2-8°C
• CAS DataBase Reference: (S)-4,4,4-TRIFLUOROBUTANE-1,3-DIOL(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-4,4,4-TRIFLUOROBUTANE-1,3-DIOL(135154-88-0)
• EPA Substance Registry System: (S)-4,4,4-TRIFLUOROBUTANE-1,3-DIOL(135154-88-0)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 135154-88-0(Hazardous Substances Data)

Usage

General Description

(S)-4,4,4-TRIFLUOROBUTANE-1,3-DIOL is a compound with the chemical formula C4H9F3O2. It is a fluorinated alcohol with three fluorine atoms attached to the carbon backbone. (S)-4,4,4-TRIFLUOROBUTANE-1,3-DIOL is used primarily as a building block in the synthesis of various pharmaceuticals and agrochemicals. Its unique structure and properties make it a valuable intermediate in the production of different organic compounds. Additionally, (S)-4,4,4-TRIFLUOROBUTANE-1,3-DIOL is also used as a solvent in certain chemical reactions and processes due to its ability to dissolve a wide range of substances. Its structure and properties make it a versatile and important chemical in various industries.

InChI:InChI=1/C4H7F3O2/c5-4(6,7)3(9)1-2-8/h3,8-9H,1-2H2/t3-/m0/s1

Upstream product

• 85571-85-3 ethyl (3R)-4,4,4-trifluoro-3-hydroxybutanoate 
• 122818-66-0 (R)-6,6,6-Trifluoro-5-hydroxy-2-methyl-2-trimethylsilanyloxy-hexan-3-one 

Downstream Products

• 135859-37-9 4,4,4-trifluoro-3-hydroxybutyl 4-methylbenzenesulfonate 

Relevant articles and documents

STEREOCONTROLLED SYNTHESIS OF 4,4,4-TRIFLUOROTHREONINE

Stereoisomers of unnatural 4,4,4-trifluorothreonine are obtained through enzymatic resolution, and the absolute configuration of these materials is determined. 4,4,4-Trifluorothreonine thus prepared was evaluated for antifugal or antitumor activity.

The fluorine-containing α, β - production of unsaturated aldehydes

The purpose of the present invention is to provide a fluorine-containing alpha,beta-unsaturated aldehyde, a method for producing same, an optically active fluorine-containing compound using the fluorine-containing alpha,beta-unsaturated aldehyde, and a method for producing same. This method for producing a fluorine-containing alpha,beta-unsaturated aldehyde is a method for producing a fluorine-containing alpha,beta-unsaturated aldehyde represented by formula (1) and comprises: an oxidizing step of oxidizing an alcohol represented by formula (2) in a high-boiling-point solvent, which has a higher boiling point than the corresponding alpha,beta-unsaturated aldehyde, by using an oxidizing agent that is insoluble to the high-boiling-point solvent; and a purifying step of purifying the reaction solution obtained in the oxidizing step by distillation. In formulae (1) and (2), R1 and R2 each independently represent a hydrogen atom or a fluorine atom, and X is 2 or 3.

Process for producing 4,4,4,- trifluoro-3-hydroxybutyric acid

A first process for producing an optically active perfluoroalkylcarbinol derivative includes (a) reacting an optically active imine with a compound that is a hemiacetal of a perfluoroalkylaldehyde or a hydrate of a perfluoroalkylaldehyde to obtain a conde