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1352146-17-8

1352146-17-8

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1352146-17-8 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1352146-17-8 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,5,2,1,4 and 6 respectively; the second part has 2 digits, 1 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1352146-17:
(9*1)+(8*3)+(7*5)+(6*2)+(5*1)+(4*4)+(3*6)+(2*1)+(1*7)=128
128 % 10 = 8
So 1352146-17-8 is a valid CAS Registry Number.

1352146-17-8Downstream Products

1352146-17-8Relevant articles and documents

Synthesis and SAR development of novel P2X7 receptor antagonists for the treatment of pain: Part 2

Brumfield, Stephanie,Matasi, Julius J.,Tulshian, Deen,Czarniecki, Michael,Greenlee, William,Garlisi, Charles,Qiu, Hongchen,Devito, Kristine,Chen, Shu-Cheng,Sun, Yongliang,Bertorelli, Rosalia,Ansell, Justin,Geiss, William,Le, Van-Duc,Martin, Gregory S.,Vellekoop, Samuel A.,Haber, James,Allard, Melissa L.

, p. 7287 - 7290 (2012/02/04)

Novel P2X7 antagonists were developed using a purine scaffold. These compounds were potent and selective at the P2X7 receptor in human and rodent as well as efficacious in rodent pain models. Compound 15a was identified to have oral potency in several pain models in rodent similar to naproxen, gabapentin and pregabalin. Structure-activity relationship (SAR) development and results of pain models are presented.

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