135245-97-5

Basic information

• Product Name: L-Serine, O-[(1,1-dimethylethyl)diphenylsilyl]-N-[(phenylmethoxy)carbonyl]-, methyl ester
• CAS NO: 135245-97-5
• Molecular Formula: C28H33NO5Si
• Molecular Weight: 491.659
• Mol File: 135245-97-5.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: L-Serine, O-[(1,1-dimethylethyl)diphenylsilyl]-N-[(phenylmethoxy)carbonyl]-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: L-Serine, O-[(1,1-dimethylethyl)diphenylsilyl]-N-[(phenylmethoxy)carbonyl]-, methyl ester(135245-97-5)
• EPA Substance Registry System: L-Serine, O-[(1,1-dimethylethyl)diphenylsilyl]-N-[(phenylmethoxy)carbonyl]-, methyl ester(135245-97-5)

Safety Data

• Hazardous Substances Data: 135245-97-5(Hazardous Substances Data)

Upstream product

• 1145-80-8 N-(benzyloxycarbonyl)-L-serine 
• 1676-81-9 N-benzyloxycarbonyl-L-serine methyl ester 
• 58479-61-1 tert-butylchlorodiphenylsilane 

Downstream Products

• 122051-27-8 N-(Benzyloxycarbonyl)-O-(tert-butyldiphenylsilyl)-L-serinal 
• 140408-49-7 (S)-methyl 2-amino-3-((tert-butyldiphenylsilyl)oxy)propanoate 
• 145790-54-1 (2S)-2-benzyloxycarbonylamino-3-(tert-butyl-diphenyl-silanyloxy)-propionic acid 
• 1621435-86-6 tert-butyl 2-((S)-1-amino-3-((tert-butyldiphenylsilyl)oxy)-1-oxopropan-2-yl)-1-oxo-2,5-diazaspiro[3.4]octane-5-carboxylate 
• 1621435-85-5 tert-butyl 2-((S)-3-((tert-butyldiphenylsilyl)oxy)-1-methoxy-1-oxo-propan-2-yl)-1-oxo-2,5-diazaspiro[3.4]octane-5-carboxylate 
• 1621435-84-4 tert-butyl 2-(((S)-3-((tert-butyldiphenylsilyl)oxy)-1-methoxy-1-oxopropan-2-yl)carbamoyl)-2-(hydroxymethyl)pyrrolidine-1-carboxylate 
• 138312-57-9 1,2:3,4-Di-O-isopropylidene-6-(N-(benzyloxycarbonyl)amino)-6-deoxy-7-O-(tert-butyldiphenylsilyl)-L-glycero-α-D-galacto-heptopyranose 
• 138286-60-9 2(R)-<1'(S)-((Benzyloxycarbonyl)amino)-2'-((tert-butyldiphenylsilyl)oxy)ethyl>-3(S)-(benzyloxy)-4(R)-hydroxy-2,3-dihydro-4H-pyran 
• 122051-28-9 2(R)-<1'(S)-((Benzyloxycarbonyl)amino)-2'-((tert-butyldiphenylsilyl)oxy)ethyl>-3(S)-(benzoyloxy)-2,3-dihydro-4H-pyran-4-one 
• 127896-79-1 [(S)-2-(tert-Butyl-diphenyl-silanyloxy)-1-((2S,4S)-4-hydroxy-3,4-dihydro-2H-pyran-2-yl)-ethyl]-carbamic acid benzyl ester 
• 138286-61-0 7-((tert-Butyldiphenylsilyl)oxy)-6(S)-((benzyloxycarbonyl)amino)-5(S)-hydroxy-2-heptenal 
• 83051-83-6 1,2:3,4-Di-O-isopropylidene-6-N-((carbobenzyloxy)amino)-6-deoxy-7-O-acetyl-L-glycero-α-D-galacto-heptopyranose 
• 76951-87-6 1,2:3,4-di-O-isopropylidene-6--6-deoxy-L-glycero-α-D-galacto-heptopyranose 
• 127896-81-5 2(S)-<1'(S)-(Benzyloxycarbonyl)amino)-2'-((tert-butyldiphenylsilyl)oxy)ethyl>-4(R)-acetoxy-2,3-dihydro-4H-pyran 

Relevant articles and documents

Simple and Practical Real-Time Analysis of Solid-Phase Reactions by Thin-Layer Chromatography

Solid-phase synthesis is a practical approach for simplifying the time-consuming and routine purification steps in the preparation of numerous naturally occurring molecules; however, studying such reactions is difficult due to the lack of a convenient monitoring method. By using thin-layer chromatography in conjunction with a photolabile linker on a resin, we developed a convenient and simple method for monitoring solid-phase reactions in real time by thin-layer chromatography. This method provides a user-friendly protocol for examining reaction conditions for solid-state syntheses.

Protection of Hydroxy Groups by Silylation: Use in Peptide Synthesis and as Lipophilicity Modifiers for Peptides

A survey of a series of organosilyl derivatives of serine and tyrosine has shown that they have a satisfactory stability profile for use in peptide synthesis.Only when alkaline conditions were used did side-reactions appear.A range of stability profiles have been determined from a study of organosilyl derivatised dipetides under different conditions, giving t1/2 values for hydrolysis ranging from 41 to 465 min in acid conditions, yet giving long-term stability at pH-values near to neutrality.

Syntheses of Destomic Acid and Anhydrogalantinic Acid from L-Serinal

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