135335-11-4

Basic information

• Product Name: Carbamic acid, [2-(4-bromophenyl)ethyl]-, ethyl ester
• CAS NO: 135335-11-4
• Molecular Formula: C11H14BrNO2
• Molecular Weight: 272.142
• Mol File: 135335-11-4.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: Carbamic acid, [2-(4-bromophenyl)ethyl]-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [2-(4-bromophenyl)ethyl]-, ethyl ester(135335-11-4)
• EPA Substance Registry System: Carbamic acid, [2-(4-bromophenyl)ethyl]-, ethyl ester(135335-11-4)

Safety Data

• Hazardous Substances Data: 135335-11-4(Hazardous Substances Data)

Upstream product

• 16532-79-9 4-Bromophenylacetonitrile 
• 73918-56-6 4-Bromophenethylamine 
• 541-41-3 chloroformic acid ethyl ester 

Downstream Products

• 258515-65-0 7-bromo-3,4-dihydroisoquinoline-2(1H)-carboxylic acid tert-butyl ester 
• 17680-55-6 7-bromo-1,2,3,4-tetrahydroisoquinoline 
• 891782-60-8 7-bromo-3,4-dihydroisoquinolin-1(2 H)-one 

Relevant articles and documents

Catalyst-free cyclization of anthranils and cyclic amines: One-step synthesis of rutaecarpine

An efficient synthesis of a variety of quinazolinone derivatives via a direct cyclization reaction between commercially available anthranils and cyclic amines is described. The developed transformation proceeds with the merits of high step- and atom-efficiency, a broad substrate scope, and good to excellent yields, without additional catalysts, and offers a practical way for the preparation of rutaecarpine and its derivatives with structural diversity.

Design, synthesis and biological evaluation of a series of novel GPR40 agonists containing nitrogen heterocyclic rings

A novel series of GPR40 agonists is designed by introducing nitrogen-containing heterocyclic ring at the terminal phenyl ring of TAK-875 with the aim of decreasing its lipophilicity. Three different β-substituted phenylpropionic acids were investigated as the acidic components. A total of 34 compounds have been synthesized, among which, compound 30 exhibited comparable GPR40 agonistic activity in vitro with TAK-875 and relatively lower lipophilicity through calculation (30, EC50 = 1.2 μM, cLogP = 1.3; TAK-875: EC50 = 5.1 μM, cLogP = 3.4). Moreover, compound 30 was able to enhance the insulin secretion of primary islets isolated from normal ICR mice and showed no obvious inhibition against cytochromes P450 in vitro. In vivo, compound 30 exhibited efficacy in oral glucose tolerance test (oGTT) in normal ICR mice.

USE OF ARYL CARBAMATES IN AGRICULTURE AND OTHER PLANT-RELATED AREAS

Disclosure is provided for methods of preventing, removing or inhibiting microbial biofilm formation or microbial infection in a plant or plant part thereof, including applying thereto a treatment effective amount of an aryl carbamate as described herein,