1354719-92-8

Basic information

• Product Name: 4-(4-bromophenyl)-2-[3-[4-[3-(acetylamino)phenyl]piperidin-1-yl]propyl]phthalazin-1(2H)-one
• Synonyms: 4-(4-bromophenyl)-2-[3-[4-[3-(acetylamino)phenyl]piperidin-1-yl]propyl]phthalazin-1(2H)-one
• CAS NO: 1354719-92-8
• Molecular Weight: 559.506
• Mol File: 1354719-92-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-(4-bromophenyl)-2-[3-[4-[3-(acetylamino)phenyl]piperidin-1-yl]propyl]phthalazin-1(2H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-bromophenyl)-2-[3-[4-[3-(acetylamino)phenyl]piperidin-1-yl]propyl]phthalazin-1(2H)-one(1354719-92-8)
• EPA Substance Registry System: 4-(4-bromophenyl)-2-[3-[4-[3-(acetylamino)phenyl]piperidin-1-yl]propyl]phthalazin-1(2H)-one(1354719-92-8)

Safety Data

• Hazardous Substances Data: 1354719-92-8(Hazardous Substances Data)

Upstream product

• 76462-38-9 1,2-dihydro-4-(4-bromophenyl)(2H)phthalazin-1-one 
• 387827-25-0 N-[3-(piperidin-4-yl)phenyl]-acetamide 
• 1354720-51-6 4-(4-bromophenyl)-2-(3-chloropropyl)phthalazin-1(2H)-one 

Relevant articles and documents

4-Arylphthalazin-1(2H)-one derivatives as potent antagonists of the melanin concentrating hormone receptor 1 (MCH-R1)

A novel series of 4-arylphthalazin-1(2H)-one linked to arylpiperidines were synthesized and evaluated as MCH-R1 antagonists. The results of an extensive SAR study probing the effects of substituents on the 4-arylphthalazin-1(2H)-one C-4 aryl group led to the identification of the 4-(3,4-difluorophenyl) derivative as a highly potent MCH-R1 inhibitor with an IC50 = 1 nM. However, further investigations showed that this substance has unacceptable pharmacokinetic properties including a high clearance and volume of distribution.