1354972-75-0Relevant articles and documents
Isothiouronium modification empowers pyrimidine-substituted curcumin analogs potent cytotoxicity and Golgi localization
Tong, Sheng,Zhang, Meng,Wang, Shixi,Yin, Ruijuan,Yu, Rilei,Wan, Shengbiao,Jiang, Tao,Zhang, Lijuan
, p. 849 - 857 (2016)
Most of protein post-translational modifications occur in the Golgi and many human diseases are associated with abnormal Golgi function or improper post translational modifications of proteins in the Golgi. In this study, we designed and synthesized 4?×?6
Synthesis of a novel series of (E, E)-4,6-bis(styryl)-2-O-glucopyranosyl- pyrimidines and their potent multidrug resistance (MDR) reversal activity against cancer cells
Gao, Lei,Liu, Qian,Ren, Sumei,Wan, Shengbiao,Jiang, Tao,Wong, Iris L. K.,Chow, Larry M. C.,Wang, Shixi
, p. 620 - 633 (2013/01/16)
A novel series of methoxy or benzyloxy substituted (E,E)-4,6-bis(styryl)-2- O-glucopyranosyl-pyrimidines as curcuminoid analogs were synthesized in four steps with total yields of 21.5% to 33.9%. A549 and HL60 cells were employed for the anticancer activity testing. The results demonstrated that 5a, 5c, and 5e have some inhibitory activity against the HL-60 cell line. Unfortunately, no compound displayed inhibitory activity against A549 except for 5c. MDR reversal activity results demonstrated that compounds 4a (RF = 12.3) and 4b (RF = 18.5) showed strong reversal activity to the P-gp-mediated LCC6MDR cells compared to verapamil (RF = 3.2) and no cytotoxicity to cancer or normal cell lines even at a high concentrations (100M).