1355331-53-1

Basic information

• Product Name: C₁₇H₁₆ClN₅O₆
• CAS NO: 1355331-53-1
• Molecular Weight: 421.797
• Mol File: 1355331-53-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₇H₁₆ClN₅O₆(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₇H₁₆ClN₅O₆(1355331-53-1)
• EPA Substance Registry System: C₁₇H₁₆ClN₅O₆(1355331-53-1)

Safety Data

• Hazardous Substances Data: 1355331-53-1(Hazardous Substances Data)

Upstream product

• 7693-45-0 4-Chlorophenyl chloroformate 
• 30516-87-1 3'-azido-2',3'-deoxythymidine 

Relevant articles and documents

Synthesis and evaluation of potential inhibitors of human and Escherichia coli histidine triad nucleotide binding proteins

Based on recent substrate specificity studies, a series of ribonucleotide based esters and carbamates were synthesized and screened as inhibitors of the phosphoramidases and acyl-AMP hydrolases, Escherichia coli Histidine Triad Nucleotide Binding Protein (ecHinT) and human Histidine Triad Nucleotide Binding Protein 1 (hHint1). Using our established phosphoramidase assay, Ki values were determined. All compounds exhibited non-competitive inhibition profiles. The carbamate based inhibitors were shown to successfully suppress the Hint1-associated phenotype in E. coli, suggesting that they are permeable intracellular inhibitors of ecHinT.