13565-08-7

Basic information

• Product Name: 4-FLUOROCINNAMOYL CHLORIDE 97
• Synonyms: 4-FLUOROCINNAMOYL CHLORIDE 98+%;4-Fluorocinnamoyl chloride;4-FluorocinnaMoyl chloride 97%, predoMinantly trans;4-Fluorocinnamoyl Chloride Predominantly Trans;(E)-3-(4-fluorophenyl)prop-2-enoyl chloride;3-(4-fluorophenyl)prop-2-enoyl chloride;4-FLUOROCINNAMOYL CHLORIDE 97
• CAS NO: 13565-08-7
• Molecular Formula: C₉H₆ClFO
• Molecular Weight: 184.59
• Product Categories: Acid Halides;Carbonyl Compounds;Organic Building Blocks
• Mol File: 13565-08-7.mol
• Article Data: 85

Chemical Properties

• Melting Point: 42-46 °C(lit.)
• Boiling Point: 90 °C0.1 mm Hg(lit.)
• Flash Point: >230 °F
• Appearance: /
• Density: 1.289 g/cm³
• Vapor Pressure: 0.015mmHg at 25°C
• Refractive Index: 1.57
• CAS DataBase Reference: 4-FLUOROCINNAMOYL CHLORIDE 97(CAS DataBase Reference)
• NIST Chemistry Reference: 4-FLUOROCINNAMOYL CHLORIDE 97(13565-08-7)
• EPA Substance Registry System: 4-FLUOROCINNAMOYL CHLORIDE 97(13565-08-7)

Safety Data

• Hazard Codes: T
• Statements: 25-34-36/38
• Safety Statements: 26-36/37/39-45
• RIDADR: UN 2928 6.1/PG 2
• WGK Germany: 2
• Hazardous Substances Data: 13565-08-7(Hazardous Substances Data)

Usage

General Description

4-Fluorocinnamoyl chloride 97 is a chemical compound with the formula C9H6ClFO. It is an organic compound containing a fluorine atom substituted on the cinnamoyl group. This chemical is commonly used in various research and industrial applications, such as in the production of pharmaceuticals and agrochemicals. It is also used as a building block in the synthesis of other organic compounds. 4-Fluorocinnamoyl chloride 97 is a highly reactive compound that should be handled and stored with care due to its potential hazards.

InChI:InChI=1/C9H6ClFO/c10-9(12)6-3-7-1-4-8(11)5-2-7/h1-6H/b6-3+

Upstream product

• 459-32-5 4-fluorocinnamic acid 
• 459-57-4 4-fluorobenzaldehyde 
• 459-32-5 (E)-4-fluorocinnamic acid 
• 24654-55-5 trans-4-fluorocinnamaldehyde 

Downstream Products

• 63293-82-3 C₂₃H₂₆FNO₄ 
• 642941-68-2 3-(4-(fluoro)phenyl)acrylamide 
• 315706-75-3 3-(4-fluoro-phenyl)-N-(4-propyl-cyclohexyl)-acrylamide 
• 101488-65-7 3-(4-fluorophenyl)propan-1-amine 
• 1153623-53-0 N-(3-acetylphenyl)-3-(4-fluorophenyl)acrylamide 
• 1080637-17-7 methyl 5-hydroxy-7-(4-fluorophenyl)-3-oxohepta-4,6-dienoate 
• 1186073-46-0 (E)-3-(4-fluorophenyl)-N-(4-methyl-3-(4-(pyridin-3-yl)pyrimidin-2-ylamino)phenyl)acrylamide 
• 939964-21-3 C₁₉H₂₂FNO₃S 
• 148700-72-5 C₁₇H₁₆FNO₂ 

Relevant articles and documents

Study of the interaction between sodium salts of (2E)-3-(4'-halophenyl) prop-2-enoyl sulfachloropyrazine and bovine serum albumin by fluorescence spectroscopy

Three sodium salts of (2E)-3-(4'-halophenyl)prop-2-enoyl sulfachloropyrazine (CCSCP) were synthesized and their structures were determined by 1H and 13C NMR, LC-MS and IR. The binding properties between CCSCPs and bovine serum albumi

Design, Synthesis, and Anticancer Activity of Cinnamoylated Barbituric Acid Derivatives

This work deals with the design and synthesis of 18 barbituric acid derivatives bearing 1,3-dimethylbarbituric acid and cinnamic acid scaffolds to find potent anticancer agents. The target molecules were obtained through Knoevenagel condensation and acylation reaction. The cytotoxicity was assessed by the MTT assay. Flowcytometry was performed to determine the cell cycle arrest, apoptosis, ROS levels and the loss of MMP. The ratios of GSH/GSSG and the MDA levels were determined by using UV spectrophotometry. The results revealed that introducing substitutions (CF3, OCF3, F) on the meta- of the benzyl ring of barbituric acid derivatives led to a considerable increase in the antiproliferative activities compared with that of corresponding ortho- and para-substituted barbituric acid derivatives. Mechanism investigation implied that the 1c could increase the ROS and MDA level, decrease the ratio of GSH/GSSG and MMP, and lead to cell cycle arrest. Further research is needed for structural optimization to enhance hydrophilicity, thereby improve the biological activity of these compounds.

Photoredox Cyclization of N-Arylacrylamides for Synthesis of Dihydroquinolinones

Metal- and additive-free photoredox cyclization of N-arylacrylamides is herein reported that provides a concise access to the formation of dihydroquinolinones. In this protocol, sustainable visible light was used as the energy source, and the organic light-emitting molecule 4CzIPN served as the efficient photocatalyst. This reaction system features exclusive 6-endo-trig cyclization selectivity with a generally good yield of a range of functionalized dihydroquinolinones and dihydrobenzoquinolinones. Mechanistical studies reveal the feasibility of both 1,3-H shift and intersystem crossing of the diradical intermediate.

Cinnamyl-containing rupestonic acid methyl ester derivative as well as preparation method and application of rupestonic acid methyl ester derivative

The invention relates to a cinnamyl-containing rupestonic acid methyl ester derivative as well as a preparation method and application thereof, the derivative is prepared by the following steps: reacting rupestonic acid with dimethyl sulfate to obtain rupestonic acid methyl ester, and then obtaining 2-hydroxyl rupestonic acid methyl ester under the oxidation of camphor sulfonyl acridine. and then reacting with cinnamyl chloride under the catalysis of DMAP to obtain 20 rupestonic acid methyl ester derivatives containing cinnamyl groups. The method has the advantages of mild reaction conditions and simple experimental steps. The obtained 1d-20d rupestonic acid methyl ester derivatives containing the cinnamyl groups are subjected to a preliminary in-vitro anti-influenza A H3N2 virus activity test. Experimental results show that the compounds show good activity in 7d, 15d and 18d, and can be used as drugs for resisting influenza A H3N2 virus.