1357378-64-3

Basic information

• Product Name: 2‐(4‐(methylthio)phenyl)benzo[d]oxazole
• Synonyms: 2‐(4‐(methylthio)phenyl)benzo[d]oxazole
• CAS NO: 1357378-64-3
• Molecular Weight: 241.313
• Mol File: 1357378-64-3.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2‐(4‐(methylthio)phenyl)benzo[d]oxazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2‐(4‐(methylthio)phenyl)benzo[d]oxazole(1357378-64-3)
• EPA Substance Registry System: 2‐(4‐(methylthio)phenyl)benzo[d]oxazole(1357378-64-3)

Safety Data

• Hazardous Substances Data: 1357378-64-3(Hazardous Substances Data)

Upstream product

• 3446-90-0 4-(methylthio)benzyl alcohol 
• 95-55-6 2-amino-phenol 
• 1492192-84-3 C₁₄H₁₂BrNOS 
• 3446-89-7 4-(Methylthio)benzaldehyde 
• 90005-49-5 4-(methylthio)benzamide 
• 583-53-9 2,3-dibromobenzene 
• 104-95-0 (4-bromophenyl)thioanisole 

Relevant articles and documents

Continuous flow/waste-minimized synthesis of benzoxazoles catalysed by heterogeneous manganese systems

Herein, we present our results on the development of a waste minimized protocol for the synthesis of 2-arylbenzoxazoles in continuous flow. Manganese-based heterogeneous catalysts were used in combination with cyclopentylmethyl ether as an environmentally friendly and safe reaction medium. The use of oxygen promotes the oxidative process ensuring at the same time a complete regeneration of the catalyst adopting a flow configuration which does not include the use of an additional mechanical pump. These features allowed for a faster synthesis compared to batch procedures with minimal metal leaching.

Sequential one-pot synthesis of benzoxazoles from aryl bromides: Successive palladium- and copper-catalyzed reactions

A convenient one-pot process has been developed for the synthesis of benzoxazoles. Starting from aryl bromides and 1,2-dibromobenzenes palladium-catalyzed aminocarbonylation and subsequent copper-catalyzed coupling reaction gave a variety of substituted benzoxazoles in moderate to good yields.