1357613-93-4Relevant articles and documents
Thioamide quenching of intrinsic protein fluorescence
Goldberg, Jacob M.,Wissner, Rebecca F.,Klein, Alyssa M.,Petersson, E. James
supporting information; experimental part, p. 1550 - 1552 (2012/03/26)
Thioamides quench tryptophan and tyrosine fluorescence in a distance-dependent manner and thus can be used to monitor the binding of thioamide-containing peptides to proteins. Since thioamide analogs of the natural amino acids can be synthetically incorporated into peptides, they can function as minimally-perturbing probes of protein/peptide interactions.