135835-43-7 Usage
Description
3-(3-Thienyl)-2-Propenoic Acid, Methyl Ester, also known as 3-Thiopheneacrylic Acid Methyl Ester, is a synthetic intermediate that plays a significant role in the pharmaceutical industry. It is a chemical compound derived from the thiophene family, characterized by its sulfur-containing heterocyclic structure. 3-(3-THIENYL)-2-PROPENOIC ACID, METHYL ESTER is known for its versatile reactivity and is widely utilized in the synthesis of various pharmaceutical compounds.
Uses
Used in Pharmaceutical Synthesis:
3-(3-Thienyl)-2-Propenoic Acid, Methyl Ester is used as a synthetic intermediate for the development of pharmaceutical compounds. Its unique chemical structure allows it to be a key component in the creation of various drugs, particularly those targeting specific medical conditions.
Used in the Synthesis of Anticancer Agents:
In the field of oncology, 3-(3-Thienyl)-2-Propenoic Acid, Methyl Ester is employed in the synthesis of anticancer agents. Its ability to interact with various biological targets makes it a valuable component in the development of drugs that can effectively combat cancer cells.
Used in the Synthesis of Anti-Inflammatory Drugs:
In the area of anti-inflammatory medications, this synthetic intermediate is utilized in the development of drugs that can help alleviate inflammation and reduce pain. Its versatile reactivity allows for the creation of compounds that can target specific inflammatory pathways, providing relief from various conditions.
Used in the Synthesis of Antimicrobial Agents:
3-(3-Thienyl)-2-Propenoic Acid, Methyl Ester is also used in the synthesis of antimicrobial agents, which are essential in combating bacterial and fungal infections. Its incorporation into these drugs aids in the development of compounds that can effectively target and eliminate harmful microorganisms.
Used in the Synthesis of Central Nervous System (CNS) Active Compounds:
In the field of neuroscience, this synthetic intermediate is employed in the synthesis of compounds that can modulate the central nervous system. Its unique properties enable the development of drugs that can address various neurological and psychiatric conditions, such as anxiety, depression, and epilepsy.
Check Digit Verification of cas no
The CAS Registry Mumber 135835-43-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,5,8,3 and 5 respectively; the second part has 2 digits, 4 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 135835-43:
(8*1)+(7*3)+(6*5)+(5*8)+(4*3)+(3*5)+(2*4)+(1*3)=137
137 % 10 = 7
So 135835-43-7 is a valid CAS Registry Number.
InChI:InChI=1/C8H8O2S/c1-10-8(9)3-2-7-4-5-11-6-7/h2-6H,1H3/b3-2+
135835-43-7Relevant articles and documents
Enantioselective Synthesis of Pyroglutamic Acid Esters from Glycinate via Carbonyl Catalysis
Ma, Jiguo,Zhou, Qinghai,Song, Guanshui,Song, Yongchang,Zhao, Guoqing,Ding, Kuiling,Zhao, Baoguo
supporting information, p. 10588 - 10592 (2021/04/06)
Direct α-functionalization of NH2-free glycinates with relatively weak electrophiles such as α,β-unsaturated esters still remains a big challenge in organic synthesis. With chiral pyridoxal 5 d as a carbonyl catalyst, direct asymmetric conjugated addition at the α-C of glycinate 1 a with α,β-unsaturated esters 2 has been successfully realized, to produce various chiral pyroglutamic acid esters 4 in 14–96 % yields with 81–97 % ee's after in situ lactamization. The trans and cis diastereomers can be obtained at the same time by chromatography and both of them can be easily converted into chiral 4-substituted pyrrolidin-2-ones such as Alzheimer's drug Rolipram (11) with the same absolute configuration via tert-butyl group removal and subsequent Barton decarboxylation.
TARGETING GLI PROTEINS IN HUMAN CANCER BY SMALL MOLECULES
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Paragraph 00216, (2013/03/26)
The present disclosure provides compositions, pharmaceutical preparations and methods for the diagnosis and treatment of cancers expressing a GLI polypeptide. The disclosed compositions and pharmaceutical preparations may comprise one or more pyrazolyl-containing compounds, or an analog or derivative thereof.
A palladium-catalyzed approach to polycyclic sulfur heterocycles
Martins, Andrew,Lautens, Mark
scheme or table, p. 8705 - 8710 (2009/04/11)
(Chemical Equation Presented) The synthesis of a variety of polycyclic thiophenes and benzothiophenes is accomplished via a palladium-catalyzed domino ortho-alkylation/direct arylation reaction. An examination of the intramolecular direct arylation of thi
