135859-36-8

Basic information

• Product Name: (R)-4,4,4-TRIFLUOROBUTANE-1,3-DIOL
• Synonyms: (R)-4,4,4-TRIFLUOROBUTANE-1,3-DIOL;R-TFBDOL;(3R)-4,4,4-Trifluorobutane-1,3-diol;(2R)-2,4-Dihydroxy-1,1,1-trifluorobutane, R-TFBDOL;(3R)-4,4,4-Trifluorobutane-1,3-diol, tech;(R)-4,4,4-Trifluorobutane-1,3-diol, Technical grade;1,3-Butanediol,4,4,4-trifluoro-, (3R)-
• CAS NO: 135859-36-8
• Molecular Formula: C₄H₇F₃O₂
• Molecular Weight: 144.09
• Mol File: 135859-36-8.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 94-95/4.5mm
• Flash Point: 67.6 °C
• Appearance: /
• Density: 1.354 g/cm³
• PKA: 12.06±0.20(Predicted)
• CAS DataBase Reference: (R)-4,4,4-TRIFLUOROBUTANE-1,3-DIOL(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-4,4,4-TRIFLUOROBUTANE-1,3-DIOL(135859-36-8)
• EPA Substance Registry System: (R)-4,4,4-TRIFLUOROBUTANE-1,3-DIOL(135859-36-8)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 135859-36-8(Hazardous Substances Data)

Usage

General Description

The chemical (R)-4,4,4-TRIFLUOROBUTANE-1,3-DIOL, also known as (R)-TFB, is a chiral, non-toxic, and stable compound that is commonly used in the pharmaceutical and agrochemical industries. It is mainly utilized as a building block in the synthesis of various chemicals, including anti-cancer drugs and insecticides. (R)-TFB is also used as a solvent and a fluorine source in the production of pharmaceuticals and agricultural chemicals. Additionally, its unique structure and properties make it an important intermediate in the development of new materials and fine chemicals.

Upstream product

• 85571-85-3 ethyl (3R)-4,4,4-trifluoro-3-hydroxybutanoate 
• 122818-66-0 (R)-6,6,6-Trifluoro-5-hydroxy-2-methyl-2-trimethylsilanyloxy-hexan-3-one 

Downstream Products

• 135859-37-9 4,4,4-trifluoro-3-hydroxybutyl 4-methylbenzenesulfonate 

Relevant articles and documents

The fluorine-containing α, β - production of unsaturated aldehydes

The purpose of the present invention is to provide a fluorine-containing alpha,beta-unsaturated aldehyde, a method for producing same, an optically active fluorine-containing compound using the fluorine-containing alpha,beta-unsaturated aldehyde, and a method for producing same. This method for producing a fluorine-containing alpha,beta-unsaturated aldehyde is a method for producing a fluorine-containing alpha,beta-unsaturated aldehyde represented by formula (1) and comprises: an oxidizing step of oxidizing an alcohol represented by formula (2) in a high-boiling-point solvent, which has a higher boiling point than the corresponding alpha,beta-unsaturated aldehyde, by using an oxidizing agent that is insoluble to the high-boiling-point solvent; and a purifying step of purifying the reaction solution obtained in the oxidizing step by distillation. In formulae (1) and (2), R1 and R2 each independently represent a hydrogen atom or a fluorine atom, and X is 2 or 3.

Process for producing 4,4,4,- trifluoro-3-hydroxybutyric acid

A first process for producing an optically active perfluoroalkylcarbinol derivative includes (a) reacting an optically active imine with a compound that is a hemiacetal of a perfluoroalkylaldehyde or a hydrate of a perfluoroalkylaldehyde to obtain a conde

Stereoselective Preparation of Ethyl 2,3-Dihydroxy-4,4,4-trifluorobutyrates via Enzymatic Optical Resolution

Ethyl 2,3-dihydroxy-4,4,4-trifluorobutyrate was prepared in a highly diastereo- as well as enantioselective manner via enzymatic optical resolution followed by chemical transformations with complete retention of their configurations.