1359759-81-1

Basic information

• Product Name: 1-(2,2-dimethylpropyl)-5-{3-[(2-fluorobenzyl)oxy]phenyl}-3-methyl-1,3-dihydro-2H-benzimidazol-2-one
• Synonyms: 1-(2,2-dimethylpropyl)-5-{3-[(2-fluorobenzyl)oxy]phenyl}-3-methyl-1,3-dihydro-2H-benzimidazol-2-one
• CAS NO: 1359759-81-1
• Molecular Weight: 418.511
• Mol File: 1359759-81-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(2,2-dimethylpropyl)-5-{3-[(2-fluorobenzyl)oxy]phenyl}-3-methyl-1,3-dihydro-2H-benzimidazol-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2,2-dimethylpropyl)-5-{3-[(2-fluorobenzyl)oxy]phenyl}-3-methyl-1,3-dihydro-2H-benzimidazol-2-one(1359759-81-1)
• EPA Substance Registry System: 1-(2,2-dimethylpropyl)-5-{3-[(2-fluorobenzyl)oxy]phenyl}-3-methyl-1,3-dihydro-2H-benzimidazol-2-one(1359759-81-1)

Safety Data

• Hazardous Substances Data: 1359759-81-1(Hazardous Substances Data)

Upstream product

• 1359761-03-7 5-bromo-1-(2,2-dimethylpropyl)-3-methyl-1,3-dihydro-2H-benzimidazol-2-one 
• 446-51-5 2-fluorobenzyl alcohol 
• 1359759-14-0 1-(2,2-dimethylpropyl)-5-(3-hydroxyphenyl)-3-methyl-1,3-dihydro-2H-benzimidazol-2-one 
• 305790-48-1 6-bromo-1-methyl-1,3-dihydro-2H-benzo[d]imidazole-2-one 
• 337915-79-4 4-bromo-N²-methylbenzene-1,2-diamine 
• 302800-13-1 5-bromo-N-methyl-2-nitroaniline 
• 321-23-3 4-bromo-2-fluoronitrobenzene 

Relevant articles and documents

POSITIVE ALLOSTERIC MODULATORS OF MGLUR2

The present invention is directed to benzimidazolone derivatives which are positive allosteric modulators of the mGluR2 receptor, useful in the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which the mGluR2 receptor is involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which metabotropic glutamate receptors are involved, such as schizophrenia.