136057-20-0Relevant articles and documents
An Approach to a Synthetic Carboxylate-binding Pocket Based on β-Avoparcin
Stone, Martin J.,Dyk, Martha S. van,Booth, Paul M.,Williams, Dudley H.
, p. 1629 - 1635 (2007/10/02)
An approach to a macrocyclic lactam designed to bind to a carboxylate anion is described.The diaryl ether 8 was synthesised by Ullmann coupling of the protected 3-hydroxyphenylglycine derivative 7 and (E)-4-bromocinnamic acid methyl ester.Elaboration of an optically pure (R)-tyrosine synthon was achieved by transfer of electrophilic azide to the N-acyl oxazolidinone 12.The synthesis of a model system is also described.