136112-90-8

Basic information

• Product Name: 4-(1,2,4-triazol-1-yl)-1-(β-D-2,3,5-tri-O-benzoylribofuranosyl)pyrimidine-2(1H)-one
• Synonyms: 4-(1,2,4-triazol-1-yl)-1-(β-D-2,3,5-tri-O-benzoylribofuranosyl)pyrimidine-2(1H)-one
• CAS NO: 136112-90-8
• Molecular Weight: 607.579
• Mol File: 136112-90-8.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 4-(1,2,4-triazol-1-yl)-1-(β-D-2,3,5-tri-O-benzoylribofuranosyl)pyrimidine-2(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(1,2,4-triazol-1-yl)-1-(β-D-2,3,5-tri-O-benzoylribofuranosyl)pyrimidine-2(1H)-one(136112-90-8)
• EPA Substance Registry System: 4-(1,2,4-triazol-1-yl)-1-(β-D-2,3,5-tri-O-benzoylribofuranosyl)pyrimidine-2(1H)-one(136112-90-8)

Safety Data

• Hazardous Substances Data: 136112-90-8(Hazardous Substances Data)

Upstream product

• 38953-75-2 (2R,3R,4R,5R)-2-((benzoyloxy)methyl)-5-(5-iodo-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3,4-diyl dibenzoate 
• 1372629-16-7 1-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-5-iodo-4-(1,2,4-triazol-1-yl)pyrimidin-2(1H)-one 
• 72741-18-5 tri(1H-1,2,4-triazol-1-yl)phosphine oxide 
• 1748-04-5 tribenzoyl uridine 
• 288-88-0 1,2,4-Triazole 
• 288-88-0 1,2,4-Triazole 

Downstream Products

• 211676-84-5 1-[(2R,3R,4R,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-(tert-butyl-dimethyl-silanyloxy)-4-hydroxy-tetrahydro-furan-2-yl]-4-methoxy-1H-pyrimidin-2-one 
• 173169-41-0 1-{(2R,3R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3,4-dihydroxy-tetrahydro-furan-2-yl}-4-methoxy-1H-pyrimidin-2-one 
• 2873-31-6 2′,3′,5′-tri-O-benzoyl-2-oxo-4-metoxypyrimidine 

Relevant articles and documents

Incorporation of methylated pyrimidine analogues into RNA

Routes for the preparation of 2'-silyl protected phosphoramidites of the modified nucleosides O2-methyluridine and O4-methyluridine are described. Methodology for the site-specific incorporation of these phosphonamidetes into a 25 nucleotide long oligoribonucleotide sequence by solid-phase synthesis is reported.

24. Synthesis of (15N2)[17O]urea, (15N2)[O2,O4-17O 2]uridine, and (15N3)[O2-17O]cytidine

A general synthetic approach for the synthesis of 15N- and 17O-doubly labelled pyrimidine nucleosides is described. The 15N isotopes in uridine and the 17O isotope in the urea-derived carbonyl group of uridine and cytidine originate from (15N2)[17O]urea (5) which was synthesized from 15NH4Cl, thiophosgene (1), and H2[17O]. The third 15N isotope of cytidine in 4-position stems from the substitution of the 1,2,4-triazole moiety of (15N2)[O2-17O]uridine derivative 8a/b with 15NH4OH. Hydrolysis of the same key intermediate 8a/b with Na[17O]H/H2[17O] introduced the second 17O isotope into the 4-position of uridine. The 15N- and 17O-NMR spectra of the target compounds 12 and 14 in phosphate-buffered H2O serve as references for heteronuclear NMR spectra of labelled RNA fragments.