1363378-07-7 Usage
Description
rel-(3r,4r)-3-(boc-amino)-5-fluoropiperidine is a chemical compound with a specific stereochemistry and functional groups that make it a valuable reagent in the pharmaceutical industry. It is characterized by its unique molecular structure, which includes a fluorinated piperidine ring and a protected amino group.
Uses
Used in Pharmaceutical Industry:
rel-(3r,4r)-3-(boc-amino)-5-fluoropiperidine is used as a reagent for the preparation of FLT3 kinase inhibitors. These inhibitors are crucial for treating FLT3 mediated diseases, which are a group of disorders that involve the overactivation of the FLT3 kinase enzyme. The compound's unique structure allows it to be a key component in the development of these therapeutic agents.
Application Reason:
The use of rel-(3r,4r)-3-(boc-amino)-5-fluoropiperidine in the development of FLT3 kinase inhibitors is due to its ability to interact with the FLT3 enzyme and modulate its activity. This interaction can help in the treatment of diseases where the FLT3 kinase is overactive, such as certain types of leukemia and other blood disorders. By incorporating this compound into the design of FLT3 inhibitors, researchers can potentially develop more effective and targeted therapies for these conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 1363378-07-7 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,6,3,3,7 and 8 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1363378-07:
(9*1)+(8*3)+(7*6)+(6*3)+(5*3)+(4*7)+(3*8)+(2*0)+(1*7)=167
167 % 10 = 7
So 1363378-07-7 is a valid CAS Registry Number.
1363378-07-7Relevant articles and documents
Enantioselective synthesis and physicochemical properties of libraries of 3-amino- and 3-amidofluoropiperidines
Orliac, Aurelie,Routier, Julie,Burgat Charvillon, Fabienne,Sauer, Wolfgang H. B.,Bombrun, Agnes,Kulkarni, Santosh S.,Gomez Pardo, Domingo,Cossy, Janine
, p. 3813 - 3824 (2014/04/03)
The enantioselective syntheses of 3-amino-5-fluoropiperidines and 3-amino-5,5-difluoropiperidines were developed using the ring enlargement of prolinols to access libraries of 3-amino- and 3-amidofluoropiperidines. The study of the physicochemical properties revealed that fluorine atom(s) decrease(s) the pKa and modulate(s) the lipophilicity of 3-aminopiperidines. The relative stereochemistry of the fluorine atoms with the amino groups at C3 on the piperidine core has a small effect on the pK a due to conformationnal modifications induced by fluorine atom(s). In the protonated forms, the C-F bond is in an axial position due to a dipole-dipole interaction between the N-H+ and C-F bonds. Predictions of the physicochemical properties using common software appeared to be limited to determine correct values of pKa and/or differences of pK a between cis- and trans-3-amino-5-fluoropiperidines.
