1364664-10-7

Basic information

• Product Name: N-cyclohexyl-2-propylpentyl carbamate
• Synonyms: N-cyclohexyl-2-propylpentyl carbamate
• CAS NO: 1364664-10-7
• Molecular Weight: 255.401
• Mol File: 1364664-10-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-cyclohexyl-2-propylpentyl carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: N-cyclohexyl-2-propylpentyl carbamate(1364664-10-7)
• EPA Substance Registry System: N-cyclohexyl-2-propylpentyl carbamate(1364664-10-7)

Safety Data

• Hazardous Substances Data: 1364664-10-7(Hazardous Substances Data)

Upstream product

• 58175-57-8 2-propyl-1-pentanol 
• 3173-53-3 Cyclohexyl isocyanate 
• 109-52-4 valeric acid 

Relevant articles and documents

Syntheses and evaluation of anticonvulsant activity of novel branched alkyl carbamates

A novel class of 19 carbamates was synthesized, and their anticonvulsant activity was comparatively evaluated in the rat maximal electroshock (MES) and subcutaneous metrazol (scMet) seizure tests and pilocarpine-induced status epilepticus (SE) model. In spite of the alkyl-carbamates' close structural features, only compounds 34, 38, and 40 were active at the MES test. The analogues 2-ethyl-3-methyl-butyl-carbamate (34) and 2-ethyl-3-methyl-pentyl- carbamate (38) also exhibited potent activity in the pilocarpine-SE model 30 min postseizure onset. Extending the aliphatic side chains of homologous carbamates from 7 to 8 (34 to 35) and from 8 to 9 carbons in the homologues 38 and 43 decreased the activity in the pilocarpine-SE model from ED50 = 81 mg/kg (34) to 94 mg/kg (35) and from 96 mg/kg (38) to 114 mg/kg (43), respectively. The most potent carbamate, phenyl-ethyl-carbamate (47) (MES ED50 = 16 mg/kg) contains an aromatic moiety in its structure. Compounds 34, 38, 40, and 47 offer the optimal efficacy-safety profile and, consequently, are promising candidates for development as new antiepileptics.