13651-05-3Relevant articles and documents
Chemoselective bromination in a two-step substitution under the influence of tetrachlorosilane and N-bromosuccinimide
Elmorsy, Saad,Badawy, Doria,Khatab, Tamer
, p. 2005 - 2012 (2006)
The synthesis of gem dibromide carbonyl compounds via a cheep and readily available combined reagent from tetrachlorosilane and N-bromosuccinimide (TCS-NBS). Copyright Taylor & Francis Group, LLC.
Electrochemical Oxidative Functionalization of Arylalkynes: Access to α,α-Dibromo Aryl Ketones
Wang, Dan,Wan, Zhaohua,Zhang, Heng,Lei, Aiwen
supporting information, p. 1022 - 1027 (2020/12/31)
A general and effective protocol to synthesize α,α-dibromo aryl ketones has been developed via an electrochemical oxidative method. The reaction proceeds smoothly at room temperature in an undivided cell without the addition of external oxidants. In the reaction process, LiBr acts as both bromine source and supporting electrolyte. This electrooxidation strategy has good substrate applicability and functional group compatibility. Moreover, the reaction could be scaled up efficiently in a continuous flow cell. The target product could undergo further functionalization for the synthesis of some useful heterocyclic compounds. (Figure presented.).
Switchable Synthesis of α,α-Dihalomethyl and α,α,α-Trihalomethyl Ketones by Metal-Free Decomposition of Enaminone C=C Double Bond
Liu, Yunyun,Xiong, Jin,Wei, Li,Wan, Jie-Ping
supporting information, p. 877 - 883 (2020/01/24)
The novel free radical-based cleavage of the enaminone C=C double bond is realized by using N-halosuccinimides (NXS) in the presence of benzoyl peroxide (BPO) with mild heating, enabling the tunable synthesis of α,α-dihalomethyl ketones and α,α,α-trihalomethyl ketones under different reaction conditions. The formation of these divergent products involving featured C=C double bond cleavage requires no any metal reagent, and represents one more practical example on the synthesis of poly halogenated methyl ketones via the functionalization of carbon?carbon bond. (Figure presented.).