136534-76-4

Basic information

• Product Name: N-(2-phenylethyl)-3-phenylpropylamine
• Synonyms: N-(2-phenylethyl)-3-phenylpropylamine
• CAS NO: 136534-76-4
• Molecular Weight: 239.36
• Mol File: 136534-76-4.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: N-(2-phenylethyl)-3-phenylpropylamine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-phenylethyl)-3-phenylpropylamine(136534-76-4)
• EPA Substance Registry System: N-(2-phenylethyl)-3-phenylpropylamine(136534-76-4)

Safety Data

• Hazardous Substances Data: 136534-76-4(Hazardous Substances Data)

Upstream product

• 10264-31-0 N-phenethyl-3-phenylpropanamide 
• 637-59-2 1-Bromo-3-phenylpropane 
• 64-04-0 phenethylamine 
• 3742-75-4 3-phenylpropyl 4-methylbenzenesulfonate 
• 69804-99-5 3-phenylpropanol methanesulfonate 
• 122-97-4 3-Phenyl-1-propanol 
• 2038-57-5 3-Phenylpropan-1-amine 
• 103-63-9 1-phenyl-2-bromoethane 
• 140-29-4 phenylacetonitrile 
• 104-53-0 3-phenyl-propionaldehyde 
• 501-52-0 3-Phenylpropionic acid 
• 122-78-1 phenylacetaldehyde 

Relevant articles and documents

CATALYTIC SYSTEMS FOR STEREOSELECTIVE SYNTHESIS OF CHIRAL AMINES BY ENANTIODIVERGENT RADICAL C-H AMINATION

In one aspect, the disclosure relates to a mode of asymmetric induction in radical processes based on sequential combination of enantiodifferentiative H-atom abstraction and stereoretentive radical substitution. Also disclosed is an asymmetric system for stereoselective synthesis of strained 5-membered cyclic sulfamides via radical 1,5-C—H amination of sulfamoyl azides. The disclosed metalloradical system can control the degree and sense of asymmetric induction in the catalytic radical C—H amination in a systematic manner. The disclosed system is applicable to a broad scope of substrates with different types of C(sp3)-H bonds and exhibits reactivity and selectivity, providing access to both enantiomers of useful 5-membered cyclic sulfamides in a highly enantioenriched form. Also disclosed are catalysts useful in these processes. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

Direct N-alkylation of amines with alcohols using AlCl3 as a Lewis acid

A substitution reaction of amines with alcohols for N-alkylated amines has been developed using inexpensive AlCl3 without any ligand or additive. Either aromatic or aliphatic amines and primary or secondary alcohols perform the AlCl3-mediated reaction smoothly to afford various N-alkylated amines in satisfactory yields.

Structure-activity relationships of small molecule inhibitors of RAGE-Aβ binding

The Receptor for Advanced Glycation Endproducts ('RAGE') mediates transport of amyloid-β peptide (Aβ) into the brain, and is therefore an important target for the development of therapeutic agents for Alzheimer's disease. We describe structure-activity relationships for inhibition of RAGE-Aβ binding, derived from the analysis of a library of tertiary amides.