136568-65-5 Usage
Description
(RS)-3-(4-fluorophenyl)-3-hydroxypropionitrile, with the molecular formula C9H8FNO and a molecular weight of 165.16 g/mol, is a chiral chemical compound that exists in two enantiomeric forms, (R)and (S)-. This propionitrile derivative features a hydroxy group and a fluorophenyl substituent, making it a versatile building block in organic synthesis.
Uses
Used in Pharmaceutical Synthesis:
(RS)-3-(4-fluorophenyl)-3-hydroxypropionitrile is used as a key building block for the synthesis of various pharmaceuticals, due to its ability to be incorporated into molecules with diverse biological activities.
Used in Agrochemical Production:
In the agrochemical industry, (RS)-3-(4-fluorophenyl)-3-hydroxypropionitrile is used as an intermediate for creating compounds with pesticidal properties, contributing to the development of effective crop protection agents.
Used in Medicinal Chemistry Research:
(RS)-3-(4-fluorophenyl)-3-hydroxypropionitrile serves as a valuable research tool in medicinal chemistry, where it is utilized to explore new molecular structures with potential therapeutic applications.
Used in Drug Discovery:
(RS)-3-(4-fluorophenyl)-3-hydroxypropionitrile is also used in drug discovery processes, where it aids in the design and synthesis of novel pharmaceutical intermediates for the treatment of a wide range of diseases.
Used in the Synthesis of Antimicrobial Agents:
(RS)-3-(4-fluorophenyl)-3-hydroxypropionitrile is employed as a starting material for the development of antibacterial, antifungal, and antiviral agents, highlighting its importance in the fight against infectious diseases.
Overall, (RS)-3-(4-fluorophenyl)-3-hydroxypropionitrile is a multifaceted compound with applications spanning across the pharmaceutical, agrochemical, and chemical research industries, showcasing its significance in the development of new drugs and chemicals for various purposes.
Check Digit Verification of cas no
The CAS Registry Mumber 136568-65-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,6,5,6 and 8 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 136568-65:
(8*1)+(7*3)+(6*6)+(5*5)+(4*6)+(3*8)+(2*6)+(1*5)=155
155 % 10 = 5
So 136568-65-5 is a valid CAS Registry Number.
136568-65-5Relevant articles and documents
Synthesis of β-hydroxyamides through ruthenium-catalyzed hydration/transfer hydrogenation of β-ketonitriles in water: Scope and limitations
González-Fernández, Rebeca,Crochet, Pascale,Cadierno, Victorio
, p. 90 - 101 (2019/06/18)
A cascade process for the straightforward one-pot conversion of β-ketonitriles into β-hydroxyamides is presented. The process, that proceeds in water employing the arene-ruthenium(II) complex [RuCl2(η6-p-cymene){P(4-C6H4F)2Cl}] as catalyst in combination with sodium formate, involves the initial hydration of the β-ketonitrile substrates to generate the corresponding β-ketoamide intermediates, which subsequently undergo the transfer hydrogenation (TH) of the carbonyl group. Employing a family of forty different β-ketonitriles, featuring diverse substitution patterns, the scope and limitations of the process have been established.
Ruthenium-Catalyzed Synthesis of β-Hydroxyamides from β-Ketonitriles in Water
González-Fernández, Rebeca,Crochet, Pascale,Cadierno, Victorio
supporting information, p. 6164 - 6167 (2016/12/09)
An unprecedented hydration/transfer hydrogenation tandem process for the catalytic conversion of β-ketonitriles into synthetically useful β-hydroxyamides in water has been developed, making use of the ruthenium(II) complex [RuCl2(η6-
Zinc-mediated addition of bromoacetonitrile to carbonyl compounds under solvent-free conditions
Zhang, Yumei,Du, Xi,An, Bin
, p. 73 - 75 (2014/03/21)
Zinc mediated addition reaction of bromoacetonitrile with aryl aldehydes and ketones produces β-hydroxynitriles under solvent-free conditions. The valuable feature of the methodology are solvent-free and catalyst-free conditions and short reaction times (5 min).
