13662-60-7

Basic information

• Product Name: (2E)-1-biphenyl-4-yl-3-(4-chlorophenyl)prop-2-en-1-one
• Synonyms: 1-(1,1'-Biphenyl)-4-yl-3-(4-chlorophenyl)-2-propen-1-one; 2-Propen-1-one, 1-(1,1'-biphenyl)-4-yl-3-(4-chlorophenyl)-; 4-Chloro-4'-phenylchalcone; Chalcone, 4-chloro-4'-phenyl-
• CAS NO: 13662-60-7
• Molecular Formula: C₂₁H₁₅ClO
• Molecular Weight: 318.7962
• Mol File: 13662-60-7.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 495.9°C at 760 mmHg
• Flash Point: 291.2°C
• Density: 1.193g/cm³
• Vapor Pressure: 5.67E-10mmHg at 25°C
• Refractive Index: 1.643
• CAS DataBase Reference: (2E)-1-biphenyl-4-yl-3-(4-chlorophenyl)prop-2-en-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: (2E)-1-biphenyl-4-yl-3-(4-chlorophenyl)prop-2-en-1-one(13662-60-7)
• EPA Substance Registry System: (2E)-1-biphenyl-4-yl-3-(4-chlorophenyl)prop-2-en-1-one(13662-60-7)

Safety Data

• Hazardous Substances Data: 13662-60-7(Hazardous Substances Data)

Usage

Description

(2E)-1-biphenyl-4-yl-3-(4-chlorophenyl)prop-2-en-1-one, also known as chalcone, is an organic compound characterized by a biphenyl ring and a chalcone core. It is renowned for its versatile reactivity and structural properties, making it a key component in the synthesis of a wide array of natural and synthetic compounds. Chalcone has garnered significant attention for its potential pharmacological effects, which include antioxidant, anti-inflammatory, anticancer, and antimicrobial activities. Moreover, it is being explored for its role in the development of novel drugs and bioactive molecules, underpinned by its unique structure and reactivity, positioning chalcone as an invaluable compound for chemical and biological research.

Uses

Used in Pharmaceutical Industry:
Chalcone serves as a crucial intermediate in the synthesis of various pharmaceutical compounds due to its versatile reactivity. Its potential pharmacological effects, such as antioxidant, anti-inflammatory, anticancer, and antimicrobial activities, make it a promising candidate for the development of new drugs and bioactive molecules.
Used in Chemical Research:
Chalcone's unique structure and reactivity render it an indispensable tool in chemical research. It is utilized in the synthesis of a broad spectrum of natural and synthetic compounds, contributing to the advancement of chemical knowledge and the creation of novel chemical entities.
Used in Antioxidant Applications:
Chalcone is employed as an antioxidant, leveraging its ability to combat oxidative stress and protect cells from damage. This makes it a valuable component in the development of health supplements and therapeutic agents aimed at preventing or treating diseases associated with oxidative stress.
Used in Anti-Inflammatory Applications:
Harnessing its anti-inflammatory properties, chalcone is utilized in the development of agents that can mitigate inflammation. This application is particularly relevant in the treatment of conditions characterized by chronic inflammation, such as arthritis and autoimmune disorders.
Used in Anticancer Applications:
Chalcone is explored for its potential as an anticancer agent, with studies indicating its ability to inhibit the growth and proliferation of cancer cells. It is being investigated for its role in the development of novel therapeutics targeting various types of cancer.
Used in Antimicrobial Applications:
Leveraging its antimicrobial activities, chalcone is employed in the development of agents that can combat microbial infections. This application is significant in the context of increasing antibiotic resistance and the need for new antimicrobial agents.

Upstream product

• 92-91-1 biphenyl-4-acetaldehyde 
• 104-88-1 4-chlorobenzaldehyde 
• 92-52-4 biphenyl 

Downstream Products

• 76288-01-2 3-Biphenyl-4-yl-5-(4-chloro-phenyl)-isoxazole 
• 1017240-34-4 3-Biphenyl-4-yl-5-(4-chloro-phenyl)-4,5-dihydro-1H-pyrazole 
• 76287-97-3 3-Biphenyl-4-yl-5-(4-chloro-phenyl)-4,5-dihydro-isoxazole 
• 1027392-50-2 4-biphenyl-4-yl-6-(4-chloro-phenyl)-2-oxo-cyclohex-3-enecarboxylic acid ethyl ester 
• 1027906-58-6 3-biphenyl-4-yl-5-(4-chloro-phenyl)-cyclohex-2-enone 
• 861406-41-9 C₂₅H₂₂ClN₃O 
• 77153-38-9 (cis)-1-p-Biphenylyl-2-(p-chlorophenyl)cyclopropane 
• 77153-39-0 (trans)-1-p-biphenylyl-2-(p-chlorophenyl)cyclopropane 
• 50497-93-3 4,5-dihydro-1-phenyl-3-diphenyl-5-(4-chlorophenyl)-1H-pyrazole 

Relevant articles and documents

Synthesis and characterization of 2-phenylpyrazoline derivatives and evaluation of their activities against antimicrobial and breast cancer cell line in vitro and in silico studies

The new series of 2-phenylpyrazoline derivatives (2a-j) were synthesized and evaluated for their antimicrobial, in silico and in vitro anticancer activity was performed by MTT assay using MDA-MB-231 (human breast adenocarcinoma) cell line. The 2-phenylpyr

Synthesis and characterization of 2-pyrazoline derivatives and their in silico and in vitro studies on antimicrobial and anticancer activities

The new series of 1-(4,5-dihydro-5-phenyl-3-diphenylpyrazol-1-yl)butan-1-one derivatives were synthesized by cyclization method using biphenyl chalcone with n-butyric acid and hydrazine hydrate. The synthesized 1-(4,5-dihydro-5-phenyl-3-diphenylpyrazol-1-

SAR studies of differently functionalized 4′-phenylchalcone based compounds as inhibitors of cathepsins B, H and L

Conditions related to the elevated levels of cathepsin B [3.4.22.1], cathepsin H [3.4.22.16] and cathepsin L [3.4.22.15] in various cancerous, rheumatoid arthritis and tissue degenerative disorders motivate the design, synthesis and evaluation of compound