136871-75-5

Basic information

• Product Name: 3-Piperidinamine, 2-phenyl-, (2S,3S)-
• CAS NO: 136871-75-5
• Molecular Formula: C11H16N2
• Molecular Weight: 176.261
• Mol File: 136871-75-5.mol
• Article Data: 14

Chemical Properties

• CAS DataBase Reference: 3-Piperidinamine, 2-phenyl-, (2S,3S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Piperidinamine, 2-phenyl-, (2S,3S)-(136871-75-5)
• EPA Substance Registry System: 3-Piperidinamine, 2-phenyl-, (2S,3S)-(136871-75-5)

Safety Data

• Hazardous Substances Data: 136871-75-5(Hazardous Substances Data)

Usage

General Description

3-Piperidinamine, 2-phenyl-, (2S,3S)- is a chemical compound with the molecular formula C16H22N2. It is also known as (2S,3S)-2-phenylpiperidin-3-amine and is a chiral amine. 3-Piperidinamine, 2-phenyl-, (2S,3S)- is often used in the synthesis of various pharmaceuticals and organic compounds due to its unique stereochemistry and reactivity. It is commonly used as a building block in the production of various drugs and research compounds. Additionally, it has been studied for its potential pharmacological activities and biological effects, making it a valuable compound in the field of medicinal chemistry and drug discovery.

Upstream product

• 1294517-76-2 N-benzyl-2-phenylpyridin-3-amine 
• 1415550-83-2 (2S,3S)-benzyl 3-(benzyloxycarbonylamino)-2-phenylpiperidine-1-carboxylate 
• 32634-68-7 (2S,3S)-di-4-toluoyltartaric acid 
• 872726-33-5 (+)(2S,3S)-3-(2-methoxylbenzylamino)-2-phenylpiperidine hydrochloride 
• 168267-14-9 [2S]-phenyl-piperidin-[3S]-yl-amine [2R,3R]-bis(4-methyl-benzyloxy)-succinate 
• 98-80-6 phenylboronic acid 
• 136982-36-0 (2S,3S)-3-(2-methoxybenzylamino)-2-phenylpiperidine 
• 134896-35-8 2-phenyl-3-nitropyridine 

Downstream Products

• 136982-36-0 (2S,3S)-3-(2-methoxybenzylamino)-2-phenylpiperidine 

Relevant articles and documents

Synthesis and structure-activity relationships of CP-122,721, a second-generation NK-1 receptor antagonist

The synthesis and SAR of benzylamine side chain analogs of the NK-1 receptor antagonist CP-99,994 are described. The 5-trifluoromethoxy analog, CP-122,721, shows superior in vivo blockade of NK-1 receptor mediated responses.

Asymmetric Hydrogenation of 3-Amido-2-arylpyridinium Salts by Triply Chloride-Bridged Dinuclear Iridium Complexes Bearing Enantiopure Diphosphine Ligands: Synthesis of Neurokinin-1 Receptor Antagonist Derivatives

We describe a most straightforward synthetic method for preparing neurokinin-1 (NK1) receptor antagonist derivatives by asymmetric hydrogenation of 3-amido-2-arylpyridinium salts using dinuclear iridium complexes with enantiopure diphosphine ligands, affo

PHARMACEUTICAL COMPOSITIONS COMPRISING 2-METHOXY-5- (5-TRIFLUOROMETHYL-TETRAZOL-I-YL-BENZYL) - (2S-PHENYL-PIPERIDIN-3S-YL-)

The present invention relates to pharmaceutical compositions comprising the NK1 receptor antagonist [2-Methoxy-5-(5-trifuoromethyl-tetrazol-1-yl)-benzyl]-(2S-phenyl- piperidin-3S-yl)-amine, or a pharmaceutically acceptable salt or solvate thereof, and a sodium channel blocker, as a combined preparation for simultaneous or sequential administration and to the use of such compositions in the treatment of certain disorders, including epilepsy, mood disorders and pain.