136906-01-9

Basic information

• Product Name: 7-amino-8-chloro-2-(N-n-propyl-N-propionylamino)tetralin
• Synonyms: 7-amino-8-chloro-2-(N-n-propyl-N-propionylamino)tetralin
• CAS NO: 136906-01-9
• Molecular Weight: 294.824
• Mol File: 136906-01-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 7-amino-8-chloro-2-(N-n-propyl-N-propionylamino)tetralin(CAS DataBase Reference)
• NIST Chemistry Reference: 7-amino-8-chloro-2-(N-n-propyl-N-propionylamino)tetralin(136906-01-9)
• EPA Substance Registry System: 7-amino-8-chloro-2-(N-n-propyl-N-propionylamino)tetralin(136906-01-9)

Safety Data

• Hazardous Substances Data: 136906-01-9(Hazardous Substances Data)

Upstream product

• 51512-09-5 2-(2-chlorophenyl)acetyl chloride 

Downstream Products

• 136906-08-6 (-)-U 89968E 
• 136906-08-6 (+)-U 89968E 
• 163562-15-0 U 89968E 

Relevant articles and documents

(S)- and (R)-8-(di-n-propylamino)-6,7,8,9-tetrahydro-3H-benz[e]indole-1- carbaldehyde: A new class of orally active 5-HT(1A)-receptor agonists

The enantiomers of 6,7,8,9-tetrahydro-N,N-di-n-propyl-3H-benz[e]indol-8- amine (S-(-)-2b and R-(+)-2b) and their corresponding 1-formyl analogs (S-(- )-6 and R-(+)-6 were prepared and evaluated pharmacologically for serotonergic and dopaminergic activity. The introduction of a formyl group in the 1-position shifted the pharmacological profile of 2b from a mixed D2/5- HT(1A) agonists to a selective 5-HT(1A) agonist (6). The enantiomers of 6 were agonists with full intrinsic activity and had an affinity comparable to that of 8-hydroxy-2-(di-n-propylamino)tetrahydronaphthalene (8-OH-DPAT). In contrast to 8-OH-DPAT, the enantiomers of compound 6 were found to have good oral availability.