136935-40-5

Basic information

• Product Name: 2-[(E)-(S)-2-(1,4-Dioxa-spiro[4.5]dec-2-yl)-vinyl]-benzoic acid methyl ester
• CAS NO: 136935-40-5
• Molecular Weight: 302.37
• Mol File: 136935-40-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-[(E)-(S)-2-(1,4-Dioxa-spiro[4.5]dec-2-yl)-vinyl]-benzoic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[(E)-(S)-2-(1,4-Dioxa-spiro[4.5]dec-2-yl)-vinyl]-benzoic acid methyl ester(136935-40-5)
• EPA Substance Registry System: 2-[(E)-(S)-2-(1,4-Dioxa-spiro[4.5]dec-2-yl)-vinyl]-benzoic acid methyl ester(136935-40-5)

Safety Data

• Hazardous Substances Data: 136935-40-5(Hazardous Substances Data)

Upstream product

• 2417-73-4 methyl 2-bromomethylbenzoate 
• 1213268-11-1 methyl 2-{(benzo[d]thiazol-2-ylsulfonyl)methyl}-benzoate 
• 78008-36-3 (R)-2,3-cyclohexylideneglyceraldehyde 
• 1213268-08-6 methyl 2-{(benzo[d]thiazol-2-ylthio)methyl}benzoate 
• 60494-73-7 (2-methoxycarbonylbenzyl)triphenylphosphonium bromide 

Relevant articles and documents

Convenient Synthesis of 3-Glycosylated Isocoumarins

A new route for the synthesis of 3-substituted and 8-hydroxy-3-substituted isocoumarins was developed by modified Julia olefination for initial C–C bond formation between aldehydes and benzylic sulfones. Palladium-catalyzed Meinwald rearrangement was used as a key step for the obtainment of ketone intermediates, which – upon base-promoted intramolecular cyclization – afforded the desired isocoumarins. The developed method paves the way to hitherto unknown 3-glycosylisocoumarins, in general, and 3-glucosylisocoumarins, in particular, wherein the glucosyl moiety is attached to the pyrone ring of the isocoumarin framework.