137225-05-9 Usage
General Description
2-(phenylamino)isonicotinonitrile is a chemical compound with the molecular formula C12H9N3. It is a heterocyclic aromatic compound with a nitrile group, and it is commonly used in organic synthesis and medicinal chemistry. 2-(phenylaMino)isonicotinonitrile is a derivative of isonicotinonitrile and contains a phenylamino group attached to the second position of the isonicotinonitrile ring. It has been studied for its potential pharmacological activities and has shown potential as a building block for the synthesis of various bioactive compounds. Additionally, 2-(phenylamino)isonicotinonitrile has been investigated for its potential as an antitubercular agent due to its structural similarity to isoniazid, a well-known antitubercular drug.
Check Digit Verification of cas no
The CAS Registry Mumber 137225-05-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,7,2,2 and 5 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 137225-05:
(8*1)+(7*3)+(6*7)+(5*2)+(4*2)+(3*5)+(2*0)+(1*5)=109
109 % 10 = 9
So 137225-05-9 is a valid CAS Registry Number.
137225-05-9Relevant articles and documents
Efficient synthesis of 2-arylamino substituted pyridinyl nitriles by Buchwald-Hartwig amination
Guo, Shuo,Wang, Yaping,Sun, Chunxia,Li, Jingya,Zou, Dapeng,Wu, Yangjie,Wu, Yusheng
supporting information, p. 3233 - 3237 (2013/06/27)
Both nitrile and arylamino groups containing pyridine derivatives are synthesized from commercially available nitrile substituted pyridyl chlorides via a palladium-BINAP catalyst (the second generation catalyst for the amination) in moderate to good yields. The mild conditions permit the presence of base sensitive functional groups. Noteably, the halogen atoms linked to the aromatic ring were maintained in the structures of the products under the amination reaction conditions.
