137234-88-9 Usage
Description
4-Ethyl-5-fluoropyridine is an organic compound with the molecular formula C?H?FN. It is a derivative of pyridine, featuring an ethyl group at the 4th position and a fluorine atom at the 5th position. 4-Ethyl-5-fluoropyridine is known for its potential applications in various industries, particularly as an impurity in the pharmaceutical sector.
Uses
Used in Pharmaceutical Industry:
4-Ethyl-5-fluoropyridine is used as an impurity in the production of Voriconazole (V760000), which is an antifungal medication. It plays a significant role in ensuring the quality and safety of the final drug product by being identified and controlled during the manufacturing process.
As a Voriconazole (V760000) impurity, 4-Ethyl-5-fluoropyrimidine (Voriconazole EP Impurity C) is essential for maintaining the purity and efficacy of the antifungal medication. The presence of this impurity is monitored and regulated to ensure that the therapeutic benefits of Voriconazole are not compromised, and the potential risks associated with impurities are minimized.
Check Digit Verification of cas no
The CAS Registry Mumber 137234-88-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,7,2,3 and 4 respectively; the second part has 2 digits, 8 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 137234-88:
(8*1)+(7*3)+(6*7)+(5*2)+(4*3)+(3*4)+(2*8)+(1*8)=129
129 % 10 = 9
So 137234-88-9 is a valid CAS Registry Number.
InChI:InChI=1/C7H8FN/c1-2-6-3-4-9-5-7(6)8/h3-5H,2H2,1H3
137234-88-9Relevant articles and documents
Process development of voriconazole: A novel broad-spectrum triazole antifungal agent
Butters, Mike,Ebbs, Julie,Green, Stuart P.,MacRae, Julie,Morland, Matthew C.,Murtiashaw, Charles W.,Pettman, Alan J.
, p. 28 - 36 (2013/09/07)
In the synthesis of (2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoro-4-pyrimidinyl)-1-(1H-1,2,4-triazol-1- yl)-2-butanol (voriconazole), the relative stereochemistry is set in the addition of a 4-(1-metalloethyl)-5-fluoropyrimidine derivative to 1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)-1-ethanone. The diastereo-control of this reaction has been examined by variation of pyrimidine substitution pattern and by changes in the metalation and reaction conditions. Excellent diastereoselection (12: 1) is obtained using an organozinc derivative of 6-(1-bromoethyl)-4-chloro-5-fluoropyrimidine. After removal of the chlorine from the pyrimidine ring, the absolute stereochemistry of voriconazole is established via a diastereomeric salt resolution process using (1R)-10-camphorsulfonic acid. Synthetic routes to the pyrimidine partner have also been evaluated. The initial six-step development route from 5-fluorouracil has been superseded by a four-step synthesis involving fluorination of methyl 3-oxopentanoate and cyclisation with formamidine acetate.
