137255-86-8Relevant articles and documents
Synthesis of Enantiopure Unnatural Amino Acids by Metallaphotoredox Catalysis
Faraggi, Tomer M.,Rouget-Virbel, Caroline,Rincón, Juan A.,Barberis, Mario,Mateos, Carlos,García-Cerrada, Susana,Agejas, Javier,De Frutos, Oscar,Macmillan, David W. C.
, p. 1966 - 1973 (2021/08/18)
We describe herein a two-step process for the conversion of serine to a wide array of optically pure unnatural amino acids. This method utilizes a photocatalytic cross-electrophile coupling between a bromoalkyl intermediate and a diverse set of aryl halides to produce artificial analogues of phenylalanine, tryptophan, and histidine. The reaction is tolerant of a broad range of functionalities and can be leveraged toward the scalable synthesis of valuable pharmaceutical scaffolds via flow technology.
SUBSTITUTED HETEROCYCLIC COMPOUNDS
-
Page/Page column 108, (2010/10/03)
The present invention relates to substituted heterocyclic compounds of Formula I or XI: or pharmaceutically acceptable salts or N-oxides or quaternary ammonium salts thereof wherein constituent members are provided hereinwith, as well as their compositions and methods of use, which are histamine II4 receptor inhibitors useful in the treatment of histamine II4 receptor-associated conditions or diseases or disorders including, for example, inflammatory diseases or disorders, pruritus, and pain.
A new approach for modification of phenylalanine peptides by Suzuki-Miyaura coupling reaction.
Kotha,Lahiri
, p. 2887 - 2890 (2007/10/03)
For the first time, we have modified phenylalanine peptides by the Suzuki-Miyaura coupling reaction which may be useful in developing combinatorial libraries of peptidomimetics.