1373257-44-3

Basic information

• Product Name: C₂₃H₂₆N₄O₅
• Synonyms: C₂₃H₂₆N₄O₅
• CAS NO: 1373257-44-3
• Molecular Weight: 438.483
• Mol File: 1373257-44-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₃H₂₆N₄O₅(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₃H₂₆N₄O₅(1373257-44-3)
• EPA Substance Registry System: C₂₃H₂₆N₄O₅(1373257-44-3)

Safety Data

• Hazardous Substances Data: 1373257-44-3(Hazardous Substances Data)

Upstream product

• 1373257-36-3 C₁₉H₁₆FN₃O₄ 
• 5332-73-0 3-methoxypropylamine 
• 453-71-4 3-nitro-4-fluorobenzoic acid 
• 59795-89-0 phenethyl isocyanide 

Relevant articles and documents

MCR Synthesis of Praziquantel Derivatives

Schistosomiasis, a high volume neglected tropical disease affecting more than 200 million people worldwide, can only be effectively treated by the tetrahydroisoquinoline drug praziquantel (PZQ). Herein, we describe an efficient approach to access PZQ derivatives by the Ugi 4-component reaction followed by the Pictet-Spengler reaction in a two-step, one-pot procedure. 30 novel PZQ derivatives are described based on the Ugi 4-component reaction and an X-ray structure of a novel derivative revealing different conformation compared with PZQ is discussed. Several analogues comparable in activity to the drug PZQ have been identified based on an in vitro Schistosoma mansoni worm viability assay.