1375461-31-6

Basic information

• Product Name: JS-59-145
• Synonyms: JS-59-145
• CAS NO: 1375461-31-6
• Molecular Weight: 344.33
• Mol File: 1375461-31-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: JS-59-145(CAS DataBase Reference)
• NIST Chemistry Reference: JS-59-145(1375461-31-6)
• EPA Substance Registry System: JS-59-145(1375461-31-6)

Safety Data

• Hazardous Substances Data: 1375461-31-6(Hazardous Substances Data)

Upstream product

• 178948-49-7 sodium 1-(4-ethyloxylcarbonylpiperazine-1-yl)diazen-1-ium-1,2-diolate 
• 13519-90-9 2,4-dicyano-1-fluorobenzene 

Relevant articles and documents

Structural modifications modulate stability of glutathione-activated arylated diazeniumdiolate prodrugs

JS-K, a diazeniumdiolate-based nitric oxide (NO)-releasing prodrug, is currently in late pre-clinical development as an anti-cancer drug candidate. This prodrug was designed to be activated by glutathione (GSH) to release NO. To increase the potency of JS-K, we are investigating the effect of slowing the reaction of the prodrugs with GSH. Herein, we report the effect of replacement of nitro group(s) by other electron-withdrawing group(s) in JS-K and its homo-piperazine analogues on GSH activation and the drugs' biological activity. We show that nitro-to-cyano substitution increases the half-life of the prodrug in the presence of GSH without compromising the compound's in vivo antitumor activity.