1378683-82-9

Basic information

• Product Name: 2,2-difluoro-1-(2-fluorophenyl)ethan-1-one
• Synonyms: 2,2-difluoro-1-(2-fluorophenyl)ethan-1-one
• CAS NO: 1378683-82-9
• Molecular Weight: 174.122
• Mol File: 1378683-82-9.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 2,2-difluoro-1-(2-fluorophenyl)ethan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2-difluoro-1-(2-fluorophenyl)ethan-1-one(1378683-82-9)
• EPA Substance Registry System: 2,2-difluoro-1-(2-fluorophenyl)ethan-1-one(1378683-82-9)

Safety Data

• Hazardous Substances Data: 1378683-82-9(Hazardous Substances Data)

Upstream product

• 111102-82-0 4-(2-fluorophenyl)-1,1,1-trifluoro-2,4-butanedione 
• 198967-24-7 2-fluoro-N-methoxy-N-methyl-benzamide 
• 65864-64-4 trimethyl(difluoromethyl)silane 
• 1072-85-1 o-fluorobromobenzene 
• 454-31-9 ethyl difluoroacetate 
• 1606165-14-3 C₁₂H₁₄FNO 
• 445-27-2 2'-Fluoroacetophenone 
• 124004-75-7 α,α,α-trifluoro-2-fluoroacetophenone 

Downstream Products

• 1448793-53-0 (S)-N-((S)-1,1-difluoro-2-(2-fluorophenyl)-4-oxobutan-2-yl)-2-methylpropane-2-sulfinamide 
• 1448793-54-1 (S)-2-methyl-N-((2S,4R)-1,1,5,5, 5-pentafluoro-2-(2-fluorophenyl)-4-hydroxypentan-2-yl)propane-2-sulfinylamide 
• 1448793-56-3 (2S,4S)-4-amino-1,1,1,5,5-pentafluoro-4-(2-fluorophenyl)pentan-2-ol 
• 1448793-57-4 (2R,4S)-4-amino-1,1,1,5,5-pentafluoro-4-(2-fluorophenyl)pentan-2-ol 
• 1448793-50-7 (S,Z)-N-(2,2-difluoro-1-(2-fluorophenyl)ethylidene)-2-methylpropane-2-sulfinamide 

Relevant articles and documents

Discovery of amino-1,4-oxazines as potent BACE-1 inhibitors

New amino-1,4-oxazine derived BACE-1 inhibitors were explored and various synthetic routes developed. The binding mode of the inhibitors was elucidated by co-crystallization of 4 with BACE-1 and X-ray analysis. Subsequent optimization led to inhibitors with low double digit nanomolar activity in a biochemical and single digit nanomolar potency in a cellular assays. To assess the inhibitors for their permeation properties and potential to cross the blood-brain-barrier a MDR1-MDCK cell model was successfully applied. Compound 8a confirmed the in vitro results by dose-dependently reducing Aβ levels in mice in an acute treatment regimen.

Direct and Chemoselective Synthesis of Tertiary Difluoroketones via Weinreb Amide Homologation with a CHF2-Carbene Equivalent

The homologation of Weinreb amides into difluoromethylketones with a formal nucleophilic CHF2 transfer agent is reported. Activating TMSCHF2 with potassium tert-amylate enables a convenient access to the difluorinated homologation re

DIHYDROOXAZINE OR OXAZEPINE DERIVATIVES HAVING BACE1 INHIBITORY ACTIVITY

The present invention provides a compound which has an effect of inhibiting amyloid beta production, especially an effect of inhibiting BACE1, and which is useful as a therapeutic or prophylactic agent for diseases induced by production, secretion and/or