13794-39-3Relevant articles and documents
A convenient and efficient synthesis of novel 1-ethoxycarbonylmethyl-3-ethyl-1,2,3,4-tetrahydro-4-oxo- 1,3,2-benzodiazaphosphorin-2-carboxamide 2-oxides
Huang, Jun-Min,Chen, Hui,Chen, Ru-Yu
, p. 1357 - 1363 (2002)
Some novel 1-ethoxycarbonylmethyl-3-ethyl-1,2,3,4-tetra- hydro-4-oxo-1,3,2-benzodiazaphosphorin-2-carboxamide 2-oxides containing α-amino acid ester or α -aminophosphonate groups have been designed incorporating the proximate carbonyl and phosphoryl groups into the benzoannulated phosphidiamide heterocycle and synthesized by a convenient one-pot procedure in good yields, in which the hydrochlorides of α-amino acid esters or hydrobromides of α -aminophosphonates reacted smoothly with bis(trichloromethyl) carbonate with the help of four molar equivalents of triethylamine to give the corresponding isocyanates that then formed the products by the addition with the phosphorus reagent containing a P-H bond.
Davidovich et al.
, (1977)
Design and synthesis of potent and selective inhibitors of integrin VLA-4
Wattanasin, Sompong,Weidmann, Beat,Roche, Didier,Myers, Stewart,Xing, Amy,Guo, Qin,Sabio, Michael,Von Matt, Peter,Hugo, Ronald,Maida, Susan,Lake, Philip,Weetall, Marla
, p. 2955 - 2958 (2007/10/03)
The synthesis and identification of a novel series of inhibitors of integrin VLA-4 are described. Their in vitro activity and selectivity against closely related integrins are also presented.
