1379796-52-7

Basic information

• Product Name: (RS)-N-benzyl 2-(t-butoxycarbonylamino)-2-(naphthalen-1-yl)acetamide
• Synonyms: (RS)-N-benzyl 2-(t-butoxycarbonylamino)-2-(naphthalen-1-yl)acetamide
• CAS NO: 1379796-52-7
• Molecular Weight: 390.482
• Mol File: 1379796-52-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (RS)-N-benzyl 2-(t-butoxycarbonylamino)-2-(naphthalen-1-yl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: (RS)-N-benzyl 2-(t-butoxycarbonylamino)-2-(naphthalen-1-yl)acetamide(1379796-52-7)
• EPA Substance Registry System: (RS)-N-benzyl 2-(t-butoxycarbonylamino)-2-(naphthalen-1-yl)acetamide(1379796-52-7)

Safety Data

• Hazardous Substances Data: 1379796-52-7(Hazardous Substances Data)

Upstream product

• 370561-84-5 methyl 2-diazo-2-(naphthalen-1-yl)acetate 
• 146621-91-2 2-(tert-butoxycarbonylamino)-2-(naphthalen-1-yl)acetic acid 
• 100-46-9 benzylamine 
• 2876-78-0 methyl 1-naphthylacetate 
• 896132-09-5 (+/-)-N-tert-butoxycarbonyl-α-1-naphthylglycine methyl ester 

Downstream Products

• 645395-86-4 (RS)-N-benzyl 2-amino-2-(naphthalen-1-yl)acetamide 
• 1379796-25-4 (RS)-N-benzyl 2-amino-2-(naphthalen-1-yl)acetamide hydrochloride 

Relevant articles and documents

Synthesis, anticonvulsant activity, and neuropathic pain-attenuating activity of N-benzyl 2-amino-2-(hetero)aromatic acetamides

N-Benzyl 2-acetamido-2-substituted acetamides, where the 2-substituent is a (hetero)aromatic moiety, are potent anticonvulsants. We report the synthesis and whole animal pharmacological evaluation of 16 analogues where the terminal 2-acetyl group was removed to give the corresponding primary amino acid derivatives (PAADs). Conversion to the PAAD structure led to a substantial drop in seizure protection in animal tests, demonstrating the importance of the N-acetyl moiety for anticonvulsant activity. However, several of the PAADs displayed notable pain-attenuating activities in a mouse model.