13807-84-6 Usage
Description
(2-Phenoxyphenyl)methanol, also known as 2-(2-hydroxybenzyl)phenol, is an organic compound with the molecular formula C13H12O2. It is a colorless to pale yellow crystalline solid and is characterized by its distinct chemical structure, which features a phenol group attached to a phenoxy group. This unique structure endows it with various chemical and biological properties, making it a versatile compound for different applications.
Uses
Used in Pharmaceutical Industry:
(2-Phenoxyphenyl)methanol is used as a key intermediate in the synthesis of triazolopyridines, which are known as myeloperoxidase inhibitors. Myeloperoxidase is an enzyme found in the immune system, and its overproduction has been linked to various inflammatory and autoimmune diseases. By inhibiting this enzyme, triazolopyridines can potentially alleviate the symptoms and progression of these conditions.
In the preparation of triazolopyridines, (2-Phenoxyphenyl)methanol serves as a crucial building block, providing the necessary phenolic and phenoxy moieties that are essential for the biological activity of the final product. The compound's reactivity and structural diversity make it an attractive candidate for the development of novel therapeutic agents targeting myeloperoxidase-related diseases.
Furthermore, the pharmaceutical industry may explore additional applications of (2-Phenoxyphenyl)methanol based on its unique chemical properties. For instance, its ability to form hydrogen bonds and engage in π-π interactions could be harnessed for the design of new drug candidates targeting various biological targets, such as receptors, enzymes, or ion channels.
Check Digit Verification of cas no
The CAS Registry Mumber 13807-84-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,3,8,0 and 7 respectively; the second part has 2 digits, 8 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 13807-84:
(7*1)+(6*3)+(5*8)+(4*0)+(3*7)+(2*8)+(1*4)=106
106 % 10 = 6
So 13807-84-6 is a valid CAS Registry Number.
InChI:InChI=1/C13H12O2/c14-10-11-6-4-5-9-13(11)15-12-7-2-1-3-8-12/h1-9,14H,10H2
13807-84-6Relevant articles and documents
Synthesis of the Polycyclic Ring Systems of Artocarpol A and D
Paduraru, M. Peggy,Wilson, Peter D.
, p. 4911 - 4913 (2003)
(Equation Presented) The first synthesis of the polycyclic ring systems of artocarpol A and D has been accomplished. These natural products were isolated recently from the root bark of Artocarpus rigida, and artocarpol A has been shown to have potent anti
AMINOPEPTIDASE A INHIBITORS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME
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Page/Page column 50, (2020/06/10)
The present invention relates to a novel compound, to a composition comprising the same, to methods for preparing the compound, and the use of this compound in therapy. In particular, the present invention relates to compound that is useful in the treatment and prevention of primary and secondary arterial hypertension, ictus, myocardial ischaemia, cardiac and renal insufficiency, myocardial infarction, peripheral vascular disease, diabetic proteinuria, Syndrome X and glaucoma.
In(OTf)3 catalyzed reductive etherification of 2-aryloxybenzaldehydes and 2-(arylthio)benzaldehydes
Prajapati, Anamika,Kumar, Mahendra,Thakuria, Ranjit,Basak, Ashok K.
, (2019/10/02)
2-Aryloxybenzaldehydes and 2-(arylthio)benzaldehydes undergo reductive etherification in presence of 5 mol% In(OTf)3 and stoichiometric amount of Et3SiH under solvent free conditions to generate novel symmetrical dibenzyl ethers and thioethers in excellent yields. In(OTf)3 is found to be superior in terms of catalytic activity over the other metal triflates tested for the reaction. Xanthenes and thioxanthenes, as anticipated, could not be obtained under these conditions.