138154-61-7

Basic information

• Product Name: 1-(2-IODOBENZYL)PYRROLIDINE
• Synonyms: 1-(2-IODOBENZYL)PYRROLIDINE
• CAS NO: 138154-61-7
• Molecular Formula: C₁₁H₁₄IN
• Molecular Weight: 287.14
• Mol File: 138154-61-7.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(2-IODOBENZYL)PYRROLIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-IODOBENZYL)PYRROLIDINE(138154-61-7)
• EPA Substance Registry System: 1-(2-IODOBENZYL)PYRROLIDINE(138154-61-7)

Safety Data

• Hazardous Substances Data: 138154-61-7(Hazardous Substances Data)

Usage

Chemical structure

A pyrrolidine ring with a benzyl group attached, which in turn has an iodine atom attached.

Usage

Commonly used in organic synthesis as a reagent and building block for the preparation of various pharmaceuticals and other organic compounds.

Reactivity

Known for its ability to undergo a variety of chemical reactions, including nucleophilic substitution.

Versatility

Acts as a versatile intermediate in the production of complex organic molecules due to its unique structure and reactivity.

Interest to researchers

Of interest to researchers and chemists in the fields of drug discovery and development.

Upstream product

• 123-75-1 pyrrolidine 
• 40400-13-3 2-Iodobenzyl bromide 
• 59473-45-9 2-(chloromethyl)iodobenzene 

Downstream Products

• 138180-91-3 1-Benzyl-pyrrolidine-2-carboxylic acid propylamide 
• 138154-65-1 (R)-2-((R)-1-Benzyl-pyrrolidin-2-yl)-3,3-dimethyl-butan-2-ol 
• 138154-66-2 1-{(1-Benzyl-pyrrolidin-2-yl)-[(E)-2,6-dimethyl-phenylimino]-methyl}-cyclohexanol 
• 1197984-73-8 (8S,9S)-6'-methoxy-9-[2-(pyrrolidin-1-ylmethyl)phenyl]cinchonan 
• 29897-82-3 N-benzylpyrrolidine 
• 1025-56-5 N-benzyl-2-phenyl-pyrrolidine 
• 1256490-88-6 N-benzyl-2-deuteropyrrolidine 
• 1256490-87-5 N-(2-deuterobenzyl)pyrrolidine 
• 1256490-90-0 3-(N-benzylpyrrolidin-2-yl)propanenitrile 

Relevant articles and documents

Synthetic use of the primary kinetic isotope effect in hydrogen atom transfer: Generation of α-aminoalkyl radicals

The extent to which deuterium can act as a protecting group to prevent unwanted 1,5-hydrogen atom transfer to aryl and vinyl radical intermediates was examined in the context of the generation of α-aminoalkyl radicals in a pyrrolidine ring. Intra- and int

An approach to α-substituted amines

A number of amines have been alkylated at the position alpha to nitrogen via free radical methodology. N-(2-iodobenzyl) and N-(2-iodobenzoyl) 'protected' amines have been used to generate radicals which rapidly undergo a 1,5-hydrogen shift to give more st

Generation and Alkylation of Carbanions α to the Nitrogen of Amines by a New Metalation Procedure

Treatment of a tertiary amine having a pendent o-iodobenzyl group on nitrogen with SmI2 generates α-amino organosamarium, which reacts with electrophiles giving the corresponding C-C bond formation products in good yield.