1381757-95-4

Basic information

• Product Name: C₂₀H₂₄ClNO₃S
• CAS NO: 1381757-95-4
• Molecular Weight: 393.934
• Mol File: 1381757-95-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₀H₂₄ClNO₃S(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₀H₂₄ClNO₃S(1381757-95-4)
• EPA Substance Registry System: C₂₀H₂₄ClNO₃S(1381757-95-4)

Safety Data

• Hazardous Substances Data: 1381757-95-4(Hazardous Substances Data)

Upstream product

• 5500-21-0 cyclopropropanecarbonitrile 
• 209391-72-0 8-[Chloro-(toluene-4-sulfinyl)-methylene]-1,4-dioxa-spiro[4.5]decane 

Relevant articles and documents

New synthesis of multi-substituted α-chlorocyclobutanones from 1-chloro-3-cyanoalkyl p-tolyl sulfoxides by 4-Exo-Dig nucleophilic ring closure of magnesium carbenoids to nitrile group as the key reaction

1-Chloro-3-cyanoalkyl p-tolyl sulfoxides were easily prepared from 1-chlorovinyl p-tolyl sulfoxides, which were synthesized from carbonyl compounds and chloromethyl p-tolyl sulfoxide, with lithium α-cyano carbanion of acetonitrile derivatives in good yields. Treatment of these sulfoxides with i-PrMgCl resulted in the formation of multi-substituted α- chlorocyclobutanones in good to high yields via the 4-Exo-Dig nucleophilic ring closure of the generated magnesium carbenoid intermediates to the nitrile group. This procedure provides a new and good way for the synthesis of multi-substituted α-chlorocyclobutanones from carbonyl compounds and substituted acetonitriles with formation of three carbon-carbon bonds in relatively short steps.