1382223-55-3Relevant articles and documents
IronO-Catalyzed Domino Aerobic Alcohol Oxidation/Oxidative Cross-Dehydrogenative Coupling for the Synthesis of α-Keto Amides
Kotha, Surya Srinivas,Chandrasekar, Selvaraj,Sahu, Samrat,Sekar, Govindasamy
, p. 7451 - 7457 (2016/02/19)
An ironO-catalyzed (TEMPO = 2,2,6,6-tetramethyl-1-piperidinyloxy), aerobic process was developed to synthesize α-keto amides. This reaction proceeds through a domino alcohol oxidation/oxidative cross-dehydrogenative coupling sequence, uses 2-hydroxyacetophenones and amines as the starting materials, and takes place under molecular oxygen, which makes the transformation highly efficient, practical, and environmentally friendly.