138228-90-7

Basic information

• Product Name: Glycine, N-methyl-N-[N-[(phenylmethoxy)carbonyl]-L-phenylalanyl]-, methyl ester
• CAS NO: 138228-90-7
• Molecular Formula: C21H24N2O5
• Molecular Weight: 384.432
• Mol File: 138228-90-7.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Glycine, N-methyl-N-[N-[(phenylmethoxy)carbonyl]-L-phenylalanyl]-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Glycine, N-methyl-N-[N-[(phenylmethoxy)carbonyl]-L-phenylalanyl]-, methyl ester(138228-90-7)
• EPA Substance Registry System: Glycine, N-methyl-N-[N-[(phenylmethoxy)carbonyl]-L-phenylalanyl]-, methyl ester(138228-90-7)

Safety Data

• Hazardous Substances Data: 138228-90-7(Hazardous Substances Data)

Upstream product

• 501-53-1 benzyl chloroformate 
• 63-91-2 L-phenylalanine 
• 5473-12-1 N-methylglycine methylester 
• 769922-77-2 (S)-benzyl (1-(1H-benzo[d][1,2,3]triazol-1-yl)-1-oxo-3-phenylpropan-2-yl)carbamate 
• 1161-13-3 N-Cbz-L-Phe 
• 13515-93-0 N-methylglycine methyl ester hydrochloride 

Downstream Products

• 99997-51-0 N^2.1-<(benzyloxy)carbonyl>-L-phenylalanylsarcosine 
• 138229-12-6 diphenyl 2.1-<(benzyloxy)carbonyl>-L-phenylalanyl-(2,2-decarboxy-N^2.2-methyl-L-phenylalanin-2,2-yl)>phosphonate 
• 138229-12-6 diphenyl 2.1-<(benzyloxy)carbonyl>-L-phenylalanyl-(2,2-decarboxy-N^2.2-methyl-D-phenylalanin-2,2-yl)>phosphonate 
• 138229-06-8 diphenyl 2.1-<(benzyloxy)carbonyl>-L-phenylalanyl-(2,2-decarboxy-N^2.2-methyl-3,2-vinyl-L-alanin-2,2-yl)>phosphonate 
• 138229-06-8 diphenyl 2.1-<(benzyloxy)carbonyl>-L-phenylalanyl-(2,2-decarboxy-N^2.2-methyl-3,2-vinyl-D-alanin-2,2-yl)>phosphonate 
• 138228-96-3 diphenyl N^2.1-<(benzyloxy)carbonyl>-L-phenylalanyl-(2,2-decarboxysarcosin-2,2-yl)phosphonate 
• 138228-93-0 N²-<(benzyloxy)carbonyl>-N¹-(methoxymethyl)-N¹-methyl-L-phenylalaninamide 

Relevant articles and documents

Practical Peptide Synthesis Mediated by a Recyclable Hypervalent Iodine Reagent and Tris(4-methoxyphenyl)phosphine

6-(3,5-Bis(trifluoromethyl)phenyl)-1H,4H-2aλ3-ioda-2,3-dioxacyclopenta[hi]indene-1,4-dione (p-BTFP-iodosodilactone, 1a) was synthesized and demonstrated to be an efficient hypervalent iodine(III) reagent for the synthesis of dipeptides from various standard amino acids, including sterically hindered amino acids, in good to high yields within 30 min in the presence of tris(4-methoxyphenyl)phosphine. In addition, the combined system of 1a/(4-MeOC6H4)3P was used to synthesize the pentapeptide leu-enkephalin in protected form. It is worth noting that 1a can be regenerated readily after reaction.

Influence of solvent viscosity on the rate of hydrolysis of dipeptides by carboxypeptidase Y

The influence of solvent viscosity on the rate of enzymatic hydrolysis of a series of dipeptides (Z-Phe-Gly, Z-Phe-Sar, Z-Phe-Ala, Z-Phe-NMeAla, Z-Phe-Aib and Z-Phe-Pro) by carboxypeptidase Y was investigated. The effect of solvent viscosity on the enzymatic hydrolysis revealed that whereas all Kcat values decreased with viscosity, those of the N-alkyl peptides decreased more than those of the N-H peptides. The kinetic behaviour implies the involvement of conformational changes of the enzyme in terms of the 'induced-fit' process. Copyright