1382859-13-3Relevant articles and documents
Synthesis and pharmacology of ethylphenidate enantiomers: The human transesterification metabolite of methylphenidate and ethanol
Patrick, Kennerly S.,Williard, Robin L.,VanWert, Adam L.,Dowd, Justin J.,Oatis Jr., John E.,Middaugh, Lawrence D.
, p. 2876 - 2881 (2005)
Ethanol elevates methylphenidate (1) plasma concentrations and yields the metabolite ethylphenidate (2). The therapeutic implications are tinder investigation. The IC50 for dopamine reuptake inhibition by (+)-2 was 27 nM compared to 367 nM for cocaine and 1730 nM for (-)-2. Binding selectivity for dopamine versus norepinephrine transporters was greater for (+)-2 than for cocaine. Intraperitoneal (+)-2 was approximately half as active as (+)-1 in stimulating mouse motor activity at 5 mg/kg, but (+)-2 was as active as (+)-1 at 10 mg/kg.
A PROCESS FOR THE PREPARATION OF D-THREO-RITALINIC ACID SALTS VIA NOVEL SALTS OF INTERMEDIATE THEREOF
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Page/Page column 10, (2014/06/23)
The present invention relates to a process for the preparation of d-threo-ritalinic acid salt thereof. More particularly, the present invention relates a process for the preparation of d-threo-ritalinic acid salt via novel organic salts of intermediate thereof.
METHOD FOR THE PRODUCTION OF D-THREO-2-PHENYL-2-PIPERIDINE-2-YL ACETATES
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Page/Page column 9-10, (2008/06/13)
Disclosed is a method for producing d-threo-[R(R*,R*)]-2-phenyl-2-piperidine-2-yl acetate and the acid addition salts thereof by converting d-threo-[R(R*,R*)]-2-phenyl-2-piperidine-2-yl ethanoic acid or an acid addition salt thereof into the corresponding
