1383544-03-3

Basic information

• Product Name: C₂₄H₂₈ClN₃O₃S
• CAS NO: 1383544-03-3
• Molecular Weight: 474.024
• Mol File: 1383544-03-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₄H₂₈ClN₃O₃S(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₄H₂₈ClN₃O₃S(1383544-03-3)
• EPA Substance Registry System: C₂₄H₂₈ClN₃O₃S(1383544-03-3)

Safety Data

• Hazardous Substances Data: 1383544-03-3(Hazardous Substances Data)

Upstream product

• 479630-08-5 4-(2-ethoxycarbonylacetyl)piperidine-1-carboxylic acid tert-butyl ester 
• 18312-46-4 (2-methoxyphenyl)hydrazine 
• 10147-37-2 Isopropylsulfonyl chloride 
• 1383544-06-6 C₂₀H₂₇N₃O₄ 

Relevant articles and documents

A novel series of pyrazolylpiperidine N-type calcium channel blockers

Selective blockers of the N-type calcium channel have proven to be effective in animal models of chronic pain. However, even though intrathecally delivered synthetic ω-conotoxin MVIIA from Conus magnus (ziconotide [Prialt]) has been approved for the treatment of chronic pain in humans, its mode of delivery and narrow therapeutic window have limited its usefulness. Therefore, the identification of orally active, small-molecule N-type calcium channel blockers would represent a significant advancement in the treatment of chronic pain. A novel series of pyrazole-based N-type calcium channel blockers was identified by structural modification of a high-throughput screening hit and further optimized to improve potency and metabolic stability. In vivo efficacy in rat models of inflammatory and neuropathic pain was demonstrated by a representative compound from this series.