138356-10-2

Basic information

• Product Name: 1-Pyrrolidineethanamine, N-[2-(3,4-dichlorophenyl)ethyl]-
• CAS NO: 138356-10-2
• Molecular Formula: C14H20Cl2N2
• Molecular Weight: 287.232
• Mol File: 138356-10-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-Pyrrolidineethanamine, N-[2-(3,4-dichlorophenyl)ethyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Pyrrolidineethanamine, N-[2-(3,4-dichlorophenyl)ethyl]-(138356-10-2)
• EPA Substance Registry System: 1-Pyrrolidineethanamine, N-[2-(3,4-dichlorophenyl)ethyl]-(138356-10-2)

Safety Data

• Hazardous Substances Data: 138356-10-2(Hazardous Substances Data)

Usage

General Description

1-Pyrrolidineethanamine, N-[2-(3,4-dichlorophenyl)ethyl]- is a chemical compound also known as N-ethyl-3,4-dichlorophenethylamine. It is a psychoactive substance that acts as a stimulant and euphoriant. The chemical is a derivative of phenethylamine and has been used as a recreational drug for its stimulating and energizing effects. It has also been studied for its potential therapeutic effects in treating various medical conditions, including depression and attention deficit hyperactivity disorder (ADHD). However,

Upstream product

• 7250-67-1 1-(2-chloroethyl)pyrrolidine hydrochloride 
• 5807-30-7 3,4-dichlorophenyl acetic acid 
• 7154-73-6 1-(2-aminoethyl)pyrrolidine 
• 138356-63-5 2-(3,4-Dichloro-phenyl)-N-(2-pyrrolidin-1-yl-ethyl)-acetamide 

Downstream Products

• 141044-92-0 N-<2-(3,4-dichlorophenyl)-1-ethyl>-N-<1-(3-hydroxypropyl)>-2-(1-pyrrolidinyl)ethylamine 
• 141044-90-8 N-<2-(3,4-dichlorophenyl)-1-ethyl>-N-<1-(ethoxypropionyl)>-2-(1-pyrrolidinyl)ethylamine 
• 141044-74-8 N-<2-(3,4-dichlorophenyl)-1-ethyl>-N-(3-fluoro-1-propyl)-2-(1-pyrrolidinyl)ethylamine 
• 153906-03-7 {[[2-(3,4-Dichloro-phenyl)-ethyl]-(2-pyrrolidin-1-yl-ethyl)-carbamoyl]-methyl}-carbamic acid tert-butyl ester 

Relevant articles and documents

Synthesis, characterization, and biological evaluation of a novel class of N-(arylethyl)-N-alkyl-2-(1-pyrrolidinyl)ethylamines: Structural requirements and binding affinity at the σ receptor

By synthesizing and testing a part-structure, N-[2-(3,4- dichlorophenyl)ethyl]-N-methyl-2-(1-pyrrolidinyl)ethylamine (3), derived from our previously reported high affinity σ receptor ligands (1S,2R)-(-)-N-[2- (3,4-dichlorophenyl)-ethyl]-N-methyl-2-(1-pyrrolidinyl)cyclohexylamine [(-)- 2] and (+)-2, we have identified a novel class of superpotent (subnanomolar affinity) σ ligands specific for the σ receptor labeled by [3H]-(+)-3-PPP. When 3 was tested for its capacity to displace [3H]-(+)-3-PPP from guinea pig brain membranes, it exhibited a K(i) of 0.34 nM, which is better than either of its parent compounds (-)-2 (K(i) = 1.3 nM) and (+)-2 (K(i) = 6.0 nM). Other compounds related to 3 such as N-[2-(3,4-dichlorophenyl)ethyl]-N- methyl-2-(1-homopiperidinyl)ethylamine (19) exhibited K(i) = 0.17 nM ([3H]- (+)-3-PPP). The determinants for high σ receptor affinity of 3 were examined by manipulation of this structure in a number of different ways. The high efficacy of these compounds for the σ receptor, their relative chemical simplicity and ease of synthesis, and their high degree of selectivity identifies N-[2-(3,4-dichlorophenyl)ethyl]-N-methyl-2-(1- pyrrolidinyl)ethylamine (3) and related compounds as a highly promising base for determination of the functional role of σ receptors as well as the development of novel therapeutic agents.