138356-99-7

Basic information

• Product Name: N1,N2,N2-TRIMETHYL-1,2-PROPANEDIAMINE
• Synonyms: N1,N2,N2-TRIMETHYL-1,2-PROPANEDIAMINE;N1,N2,N2-TRIMETHYLPROPANE-1,2-DIAMINE
• CAS NO: 138356-99-7
• Molecular Formula: C₆H₁₆N₂
• Molecular Weight: 0
• Mol File: 138356-99-7.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 120.303°C at 760 mmHg
• Flash Point: 12.042°C
• Appearance: /
• Density: 0.807g/cm³
• Vapor Pressure: 15.339mmHg at 25°C
• Refractive Index: 1.429
• CAS DataBase Reference: N1,N2,N2-TRIMETHYL-1,2-PROPANEDIAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: N1,N2,N2-TRIMETHYL-1,2-PROPANEDIAMINE(138356-99-7)
• EPA Substance Registry System: N1,N2,N2-TRIMETHYL-1,2-PROPANEDIAMINE(138356-99-7)

Safety Data

• Hazardous Substances Data: 138356-99-7(Hazardous Substances Data)

Usage

InChI:InChI=1/C6H16N2/c1-6(5-7-2)8(3)4/h6-7H,5H2,1-4H3

Upstream product

• 89909-95-5 2-Dimethylamino-propionsaeure-methylamid 
• 4584-49-0 (2-chloropropyl)dimethylamine hydrochloride 
• 74-89-5 methylamine 

Downstream Products

• 111935-78-5 N-Methyl-N-<2-dimethylamino-propyl>-2-aethoxy-2.2-diphenyl-acetamid 
• 138357-02-5 2-(3,4-Dichloro-phenyl)-N-(2-dimethylamino-propyl)-N-methyl-acetamide 
• 138356-34-0 N¹-[2-(3,4-Dichloro-phenyl)-ethyl]-N¹,N²,N²-trimethyl-propane-1,2-diamine 

Relevant articles and documents

Synthesis, characterization, and biological evaluation of a novel class of N-(arylethyl)-N-alkyl-2-(1-pyrrolidinyl)ethylamines: Structural requirements and binding affinity at the σ receptor

By synthesizing and testing a part-structure, N-[2-(3,4- dichlorophenyl)ethyl]-N-methyl-2-(1-pyrrolidinyl)ethylamine (3), derived from our previously reported high affinity σ receptor ligands (1S,2R)-(-)-N-[2- (3,4-dichlorophenyl)-ethyl]-N-methyl-2-(1-pyrrolidinyl)cyclohexylamine [(-)- 2] and (+)-2, we have identified a novel class of superpotent (subnanomolar affinity) σ ligands specific for the σ receptor labeled by [3H]-(+)-3-PPP. When 3 was tested for its capacity to displace [3H]-(+)-3-PPP from guinea pig brain membranes, it exhibited a K(i) of 0.34 nM, which is better than either of its parent compounds (-)-2 (K(i) = 1.3 nM) and (+)-2 (K(i) = 6.0 nM). Other compounds related to 3 such as N-[2-(3,4-dichlorophenyl)ethyl]-N- methyl-2-(1-homopiperidinyl)ethylamine (19) exhibited K(i) = 0.17 nM ([3H]- (+)-3-PPP). The determinants for high σ receptor affinity of 3 were examined by manipulation of this structure in a number of different ways. The high efficacy of these compounds for the σ receptor, their relative chemical simplicity and ease of synthesis, and their high degree of selectivity identifies N-[2-(3,4-dichlorophenyl)ethyl]-N-methyl-2-(1- pyrrolidinyl)ethylamine (3) and related compounds as a highly promising base for determination of the functional role of σ receptors as well as the development of novel therapeutic agents.