13836-37-8 Usage
Description
Boc-Arg(Tos)-OH, also known as Nα-(tert-Butoxycarbonyl)-Nω-(4-methoxyphenyl)-L-arginine, is an arginine derivative commonly utilized as a building block in peptide chemistry. It is a white powder that has been crystallized with approximately 10% (w/w) ethyl acetate, which contributes to its stability and reactivity in various chemical processes.
Uses
Used in Pharmaceutical Industry:
Boc-Arg(Tos)-OH is used as a building block for the synthesis of various peptide-based drugs, targeting a wide range of therapeutic applications. Its role in peptide chemistry is crucial, as it allows for the creation of complex peptide structures with specific biological activities.
Used in Research and Development:
In the field of research and development, Boc-Arg(Tos)-OH serves as an essential component in the design and synthesis of novel peptides for scientific investigations. It is particularly useful in studying the structure-activity relationships of peptides and their interactions with biological targets.
Used in Diagnostic Applications:
Boc-Arg(Tos)-OH is also employed in the development of diagnostic tools, such as peptide-based assays and tests, which can help in the early detection and monitoring of various diseases and conditions.
Used in Cosmetics Industry:
In the cosmetics industry, Boc-Arg(Tos)-OH is used as a key ingredient in the formulation of peptide-based anti-aging products. These products aim to improve skin elasticity, reduce the appearance of fine lines and wrinkles, and promote overall skin health.
Used in Agricultural Applications:
Boc-Arg(Tos)-OH can also be utilized in the development of bioactive peptides with potential applications in the agricultural sector. These peptides can be used as natural alternatives to traditional chemical pesticides, offering a more environmentally friendly approach to crop protection and management.
Check Digit Verification of cas no
The CAS Registry Mumber 13836-37-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,3,8,3 and 6 respectively; the second part has 2 digits, 3 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 13836-37:
(7*1)+(6*3)+(5*8)+(4*3)+(3*6)+(2*3)+(1*7)=108
108 % 10 = 8
So 13836-37-8 is a valid CAS Registry Number.
InChI:InChI=1/C18H28N4O6S/c1-12-7-9-13(10-8-12)29(26,27)22-16(19)20-11-5-6-14(15(23)24)21-17(25)28-18(2,3)4/h7-10,14H,5-6,11H2,1-4H3,(H,21,25)(H,23,24)(H3,19,20,22)
13836-37-8Relevant articles and documents
A highly effective method for synthesis of N(ω)-substituted arginines as building blocks for Boc/Fmoc peptide chemistry
Szekely, Zoltan,Zakhariev, Sotir,Guarnaccia, Corrado,Antcheva, Nikolinka,Pongor, Sandor
, p. 4439 - 4442 (2007/10/03)
Chemically and optically pure N(ω)-substituted arginine derivatives were prepared with high yields in two steps, starting from N(α)-protected ornithine and ArSO2N=C(SMe)2. The compounds were applied to solid phase peptide synthesis using Boc as well as Fmoc chemistries.
Stable polypeptides having c-AMP production enhancing activity and the use thereof
-
, (2008/06/13)
Disclosed are (1) a polypeptide represented by formula (I), or a pharmaceutically acceptable amide, ester or salt thereof: wherein X is hydrogen atom; or a lower alkyl group which may be substituted with a member selected from the group consisting of hydroxy group, substituted or unsubstituted amino group, carboxyl group, carbamoyl group, and substituted or unsubstituted aromatic group; and Y is one of amino acids or peptides consisting of 1 to 16 amino acid residues counted from the N-terminal side of Leu-Ala-Ala-Val-Leu-Gly-Lys-Arg-Tyr-Lys-Gln-Arg-Val-Lys-Asn-Lys SEQ ID NO: 20, and (2) a pharmaceutical composition comprising a polypeptide represented by formula (I), or a pharmaceutically acceptable amide, ester or salt thereof, which has remarkable c-AMP activity and is useful as a nerve activating agent.
Antigen determinant peptides and a process for the preparation thereof
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, (2008/06/13)
Antigen determinant peptides of the general formula I, H - Val - X - Y (I), in which X represents an octapeptidic to undecapeptidic sequence of a defined structure, Tyr-Tyr-Arg-Asp-Ser-Arg-Asn-Pro-Leu,Phe-Ile-His-Asn-Phe-Lys-Arg-Lys-Gly,Val-Pro-Arg-Arg-Lys-Ala-Lys-Ile,Leu-His-Thr-Gly-Glu-Arg-Asp-Trp-His-Leu-Gly,Ser-Gly-Lys-Ala-Arg-Gly-Trp-Phe, or Ser-Ile-Glu-Trp-Arg-Lys-Lys-Arg-Tyr-Ser, and Y stands for a hydroxyl or an amino group,available by fragment synthesis or successive condensation of the respective amino acid residues (stepwise build-up) in solution or on a solid carrier, are expected to be of use as diagnostic agents for the so-called acquired immunodeficiency syndrome (AIDS), and also to have a potential as monodeterminant antibodies and safe synthetic vaccine agents combating the human T-cell lymphotropic type III virus (HTLV-III, HIV).
