139079-39-3

Basic information

• Product Name: 7-HYDROXY QUETIAPINE
• Synonyms: 7-HYDROXY QUETIAPINE;ICI214227;11-[4-[2-(2-Hydroxyethoxy)ethyl]-1-piperazinyl]-dibenzo[b,f][1,4]thiazepin-7-ol;2-(2-(7-hydroxy-4-dibenzo(b,f)(1,4)thiazepine-11-yl-1-piperazinyl)ethoxy)ethanol;7-Hydroxyquetiapine solution;Quetiapine 7-Hydroxy Metabolite (HCl);11-(4-(2-(2-hydroxyethoxy)ethyl)piperazin-1-yl)dibenzo[b,f][1,4]thiazepin-7-ol;7-Hydroxy Quetiapine HCl
• CAS NO: 139079-39-3
• Molecular Formula: C21H25N3O3S
• Molecular Weight: 399.51
• Product Categories: Heterocyclic Compounds;Heterocycles;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals
• Mol File: 139079-39-3.mol
• Article Data: 0

Chemical Properties

• Melting Point: 56-60°C
• Boiling Point: 612.4 °C at 760 mmHg
• Flash Point: 9℃
• Appearance: /
• Density: 1.33 g/cm3
• Vapor Pressure: 7.5E-16mmHg at 25°C
• Refractive Index: 1.666
• Storage Temp.: -20°C Freezer
• Solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
• PKA: 11.18±0.20(Predicted)
• Stability: Hygroscopic
• CAS DataBase Reference: 7-HYDROXY QUETIAPINE(CAS DataBase Reference)
• NIST Chemistry Reference: 7-HYDROXY QUETIAPINE(139079-39-3)
• EPA Substance Registry System: 7-HYDROXY QUETIAPINE(139079-39-3)

Safety Data

• Hazard Codes: F,T
• Statements: 11-23/24/25-39/23/24/25
• Safety Statements: 16-36/37-45
• RIDADR: UN1230 - class 3 - PG 2 - Methanol, solution
• WGK Germany: 1
• Hazardous Substances Data: 139079-39-3(Hazardous Substances Data)

Usage

Description

7-HYDROXY QUETIAPINE is a metabolite of Quetiapine, a Benzothiazepine with mixed serotonin and dopamine receptor antagonistic properties. It is the primary active metabolite of the atypical antipsychotic medication Seroquel, which is used for the treatment of depression, bipolar disorder, and schizophrenia. This white solid substance serves as a reference standard for various applications, including forensic and forensic toxicology analysis, as well as urine drug testing.

Uses

Used in Pharmaceutical Industry:
7-HYDROXY QUETIAPINE is used as an active metabolite for its role in the treatment of depression, bipolar disorder, and schizophrenia. It functions as a mixed serotonin and dopamine receptor antagonist, contributing to the antipsychotic effects of the medication Seroquel.
Used in Forensic and Forensic Toxicology Analysis:
7-HYDROXY QUETIAPINE is used as a Certified Solution Standard for GCMS and LCMS applications. It aids in the identification and quantification of the metabolite in biological samples, which is crucial for forensic and toxicological investigations.
Used in Urine Drug Testing:
7-HYDROXY QUETIAPINE is used as a reference standard in urine drug testing to detect the presence of the metabolite and monitor the therapeutic use of Seroquel or to identify potential cases of drug abuse.
Used in Research and Development:
7-HYDROXY QUETIAPINE is used as a research compound for the development of new antipsychotic medications and to study its pharmacological properties, interactions, and potential applications in various therapeutic areas.

InChI:InChI=1/C21H25N3O3S/c25-12-14-27-13-11-23-7-9-24(10-8-23)21-17-3-1-2-4-19(17)28-20-15-16(26)5-6-18(20)22-21/h1-6,15,25-26H,7-14H2