139161-55-0

Basic information

• Product Name: 2-(2,4-difluorophenyl)acetamidine hydrochloride
• CAS NO: 139161-55-0
• Molecular Weight: 243.084
• Mol File: 139161-55-0.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2-(2,4-difluorophenyl)acetamidine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2,4-difluorophenyl)acetamidine hydrochloride(139161-55-0)
• EPA Substance Registry System: 2-(2,4-difluorophenyl)acetamidine hydrochloride(139161-55-0)

Safety Data

• Hazardous Substances Data: 139161-55-0(Hazardous Substances Data)

Usage

Physical form

White to off-white crystalline powder

Solubility

Sparingly soluble in water

Type of compound

Hydrochloride salt form of acetamidine

Usage

Reagent in organic synthesis, primarily in the pharmaceutical industry for the synthesis of medicinal compounds, and as an intermediate in the production of other chemicals

Potential

Biological activity and use in the development of new drugs

Upstream product

• 656-35-9 (2,4-difluorophenyl)acetonitrile 

Relevant articles and documents

THERAPEUTIC COMPOUNDS

The present disclosure relates to substituted heterocyclic derivative therapeutic compounds, compositions comprising said compounds, and the use of said compounds and compositions for epigenetic regulation by inhibition of bromodomain-mediated recognition of acetyl lysine regions of proteins, such as histones. Said compositions and methods are useful for the treatment of diseases mediated by aberrant cell signalling, such as inflammatory disorders, cancer and neoplastic disease.

Synthesis and structure-activity relationships of 2-pyridones: A novel series of potent DNA gyrase inhibitors as antibacterial agents

Two novel series of 2-pyridones were synthesized by transposition of the nitrogen of 4-quinolones to the bridgehead position. This subtle interchange of the nitrogen atom with a carbon atom yielded two novel heterocyclic nuclei, pyrido[1,2-a]pyrimidine and quinolizine, which had not previously been evaluated as antibacterial agents and were found to be potent inhibitors of DNA gyrase. Quinolizines with a methyl group at the 9-position such as (S)-45a (ABT-719) demonstrate exceptional broad spectrum antibacterial activity. Most notably, they are active against resistant bacteria such as methicillin-resistant Staphylococcus aureus, vancomycin-resistant strains of enterococci, and ciprofloxacin-resistant organisms. In addition, 2-pyridones also possess favorable physiochemical and pharmacokinetic properties. These 2-pyridones were synthesized from the commercially available starting materials by 10-17 linear transformations. The structure of an adduct yielded by this sequence, (S)-45a (ABT-719), was determined by X-ray crystallographic analysis.