1392825-19-2Relevant articles and documents
Friedel-Crafts-type reactions with ureas and thioureas
Raja, Erum K.,Nilsson Lill, Sten O.,Klumpp, Douglas A.
supporting information; experimental part, p. 8141 - 8143 (2012/09/07)
Despite the relatively low reactivities of urea and thiourea functional groups towards nucleophilic attack, we have found conditions in which they are useful substrates in Friedel-Crafts reactions. The Bronsted superacid, triflic acid, promotes these reactions and a mechanism is proposed involving dicationic, superelectrophilic intermediates.