1393093-66-7

Basic information

• Product Name: 1-(2-methoxy-5-nitrophenyl)hexan-1-one
• Synonyms: 1-(2-methoxy-5-nitrophenyl)hexan-1-one
• CAS NO: 1393093-66-7
• Molecular Weight: 251.282
• Mol File: 1393093-66-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(2-methoxy-5-nitrophenyl)hexan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-methoxy-5-nitrophenyl)hexan-1-one(1393093-66-7)
• EPA Substance Registry System: 1-(2-methoxy-5-nitrophenyl)hexan-1-one(1393093-66-7)

Safety Data

• Hazardous Substances Data: 1393093-66-7(Hazardous Substances Data)

Upstream product

• 142-61-0 Hexanoyl chloride 
• 1393093-65-6 1-(2-hydroxy-5-nitrophenyl)hexan-1-one 
• 74-88-4 methyl iodide 
• 100-02-7 4-nitro-phenol 

Downstream Products

• 1393093-67-8 2-bromo-1-(2-methoxy-5-nitrophenyl)hexan-1-one 
• 1393093-68-9 2-bromo-1-(2-hydroxy-5-nitrophenyl)hexan-1-one 
• 133238-87-6 2-(n-butyl)-5-nitrobenzofuran 
• 141627-42-1 (2-butyl-5-nitrobenzofuran-3-yl)(4-methoxyphenyl)methanone 
• 141645-16-1 2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran 

Relevant articles and documents

An alternative approach to synthesis of 2-n-butyl-5-nitrobenzofuran derivative: A key starting material for dronedarone hydrochloride

A practical synthesis of (2-butyl-5-nitrobenzofuran-3-yl)(4-hydroxyphenyl) methanone, a key intermediate in the preparation of anti arrhythmic drug, is described. The commercially available 4-nitrophenol (3) is converted in five steps to 2-butyl-5-nitrobenzofuran (9) which upon Friedel-Crafts acylation with 4-methoxybenzoyl chloride followed by deprotection of methyl group gives (2). Indian Academy of Sciences.