139366-35-1

Basic information

• Product Name: 8-BROMO-5-NITROQUINOLINE
• Synonyms: 8-BROMO-5-NITROQUINOLINE
• CAS NO: 139366-35-1
• Molecular Formula: C₉H₅BrN₂O₂
• Molecular Weight: 253.1
• EINECS: -0
• Mol File: 139366-35-1.mol
• Article Data: 5

Chemical Properties

• Melting Point: 136-137 °C
• Boiling Point: 370.5±27.0 °C(Predicted)
• Appearance: /
• Density: 1.747±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 0.16±0.29(Predicted)
• CAS DataBase Reference: 8-BROMO-5-NITROQUINOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 8-BROMO-5-NITROQUINOLINE(139366-35-1)
• EPA Substance Registry System: 8-BROMO-5-NITROQUINOLINE(139366-35-1)

Safety Data

• Hazardous Substances Data: 139366-35-1(Hazardous Substances Data)

Usage

General Description

8-Bromo-5-nitroquinoline is a chemical compound that belongs to the class of organic compounds known as nitroquinolines and derivatives. These are compounds containing a quinoline moiety which bears a nitro group. It is characterized by two key functional groups, bromine (Br) attached at position 8 of the quinoline ring and a nitro group (-NO2) at position 5. 8-Bromo-5-nitroquinoline appears as a crystalline solid and is possibly useful for organic synthesis in scientific research. However, specifics about its characteristics, uses, or safety measures can vary and individuals should refer to its product information sheet or other reputable resources for detailed information.

Upstream product

• 16567-18-3 8-bromoquinoline 
• 10403-47-1 2-bromo 5-nitroaniline 
• 56-81-5 glycerol 

Downstream Products

• 142315-99-9 5-nitro-8-piperidino-quinoline 
• 116632-58-7 8-bromo-5-aminoquinoline 
• 856089-87-7 [2-(5-nitro-[8]quinolylamino)-phenyl]-arsonic acid 
• 205046-59-9 8-cyano-5-nitroquinoline 

Relevant articles and documents

Auxiliary-Directed C(sp3)?H Arylation by Synergistic Photoredox and Palladium Catalysis

Herein we describe the auxiliary-directed arylation of unactivated C(sp3)?H bonds with aryldiazonium salts, which proceeds under synergistic photoredox and palladium catalysis. The site-selective arylation of aliphatic amides with α-quaternary centres is achieved with high selectivity for β-methyl C(sp3)?H bonds. This operationally simple method is compatible with carbocyclic amides, a range of aryldiazonium salts and proceeds at ambient conditions.

Synthesis of 8-heteroaryl nitroxoline analogues via one-pot sequential Pd-catalyzed coupling reactions

A series of 8-heteroaryl substituted quinolines were prepared, either by direct C-H arylation of five-membered heteroarenes, or Pd-catalyzed coupling of organoboron reagents with bromoquinolines. The use of (benzo)thiophenyl or (benzo)furanyl boron coupling partners allowed further C-H functionalization on the five-membered heteroaryl ring with aryl bromides in one flask to access a variety of polyconjugated molecular architectures. The developed methodology represents a simple approach towards 8-arylated analogues of the biologically interesting nitroxoline core.

Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function

Fused cyclic compounds, methods of using such compounds in the treatment of nuclear hormone receptor-associated conditions such as cancer and immune disorders, and pharmaceutical compositions containing such compounds.