13938-68-6

Basic information

• Product Name: 2-Furanacetyl chloride, alpha-oxo- (9CI)
• Synonyms: 2-Furanacetyl chloride, alpha-oxo- (9CI)
• CAS NO: 13938-68-6
• Molecular Formula: C₆H₃ClO₃
• Molecular Weight: 158.53922
• Product Categories: ACETYLHALIDE
• Mol File: 13938-68-6.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Furanacetyl chloride, alpha-oxo- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Furanacetyl chloride, alpha-oxo- (9CI)(13938-68-6)
• EPA Substance Registry System: 2-Furanacetyl chloride, alpha-oxo- (9CI)(13938-68-6)

Safety Data

• Hazardous Substances Data: 13938-68-6(Hazardous Substances Data)

Upstream product

• 1467-70-5 furan-2-yl-oxo-acetic acid 
• 110-00-9 furan 
• 79-37-8 oxalyl dichloride 

Downstream Products

• 856908-45-7 phenylmethyl (Z)-N-methoxy-2-furancarboximidate 
• 1140458-93-0 C₁₅H₁₂F₃N₃O₄ 
• 1352786-48-1 1-(furan-2-yl)-4-phenylbut-3-yne-1,2-dione 
• 1489263-03-7 1-(1-benzyl-1H-indol-3-yl)-2-(furan-2-yl)ethane-1,2-dione 
• 1467-70-5 furan-2-yl-oxo-acetic acid 

Relevant articles and documents

Preparation method of [alpha]-oxo-2-furanacetic acid

The invention belongs to the field of preparation of organic compounds, and particularly relates to a preparation method of [alpha]-oxo-2-furanacetic acid, which comprises the following steps: 1) preparing oxalic acid and an organic alkali solution, controlling the temperature to 5-10 DEG C, dropwisely adding a trichloromethyl carbonate solution into the oxalic acid and organic alkali solution, and keeping the temperature for 2-4 hours until the solid is completely dissolved to obtain a solution A; obtaining a first solution; 2) preparing a furan and Lewis acid solution, controlling the temperature to be 20-25 DEG C, then dropwise adding the first solution into the furan and Lewis acid solution, and carrying out heat preservation for 1-2 hours to obtain a second solution; and 3) quenching the second solution at 0-10 DEG C to obtain the [alpha]-oxo-2-furanacetic acid. The preparation method disclosed by the invention does not generate nitric oxide and composite salt, and is low in treatment difficulty, low in environmental harm, low in temperature required by the whole reaction, low in energy consumption, simple in reaction step and short in time consumption.

Enantioselective Construction of 3-Hydroxypiperidine Scaffolds by Sequential Action of Light and Rhodium upon N-Allylglyoxylamides

3-Hydroxypiperidine scaffolds were enantioselectively constructed in an atom-economical way by sequential action of light and rhodium upon N-allylglyoxylamides. In a formal sense, the allylic C-H bond was selectively cleaved and enantioselectively added a

Asymmetric friedel-crafts alkylation of α-substituted β-nitroacrylates: Access to β2,2-amino acids bearing indolic all-carbon quaternary stereocenters

A highly enantioselective Friedel-Crafts alkylation reaction of indoles with acyclic α-substituted β-nitroacrylates is developed under the catalysis of Ni(ClO4)2-bisoxazoline complex at 1 mol % catalyst loading, affording chiral indolic β-nitroesters bearing all-carbon quaternary stereocenters in excellent yields and ees of up to 97%. Transformation of one of the products to β2,2-amino ester and tetrahydro-β-carboline through nitro reduction and sequential Pictet-Spengler cyclization was exemplified.